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• W63821318 abstract "ABSTRACT The synthesis of three goldfish brain proteins, α, ependymin and its precursor molecule ependymin s, is specifically enhanced when the animals learn to swim with an attached styrofoam float. The ependymins are glycoproteins which have been isolated by affinity chromatography on concanavalin A followed by SDS-PAGE. By means of a highly specific and sensitive radioimmunoassay (RIA) we have analysed the regional and subcellular distribution of ependymins in goldfish brain. They are specific for the nervous tissue and highly enriched in the cytoplasmic and extracellular compartments in the CNS of untrained goldfish. The highest concentrations have been measured in the optic tectum and the vagal lobes. Ependymins are secreted both in situ and in cell culture. After learning of the float-training task, their steady-state concentration decreases temporarily in the extracellular brain fluid (ECF), before it increases over control values both in the cytoplasm and the ECF. Ependymin-like immunoreactivity has also been detected in other fish, in toads, and even in mammals and is especially pronounced in cultured pyramidal neurons derived from embryonic rat brain hippocampus. Rabbit anti-ependymin antisera inhibited the consolidation of the newly acquired float-swimming when injected into the IV. brain ventricle during a critical time period after learning. They also prevented long-term memory formation after a classical avoidance conditioning in the “shuttle-box” when they were injected intraventricularly at 0.5, 4.5 or 24, but not at 72 hours after or 0.5 hours before the acquisition of the task. Preimmune rabbit sere were used for control experiments. The behaviour of goldfish that flee the light stimulus spontaneously was not influenced by the injection of antiserum (active control group). - We assume that the antisera interfere with synaptic events during memory consolidation, since isolated ependymins possess substantial calcium binding capacity and resemble other acidic calcium binding proteins like S-100 to which they exhibit some immunological cross-reactivity." @default.
• W63821318 created "2016-06-24" @default.
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• W63821318 date "1986-01-01" @default.
• W63821318 modified "2023-09-23" @default.
• W63821318 title "Biochemical Participation of Glycoproteins in Memory Consolidation After Two Different Training Paradigms in Goldfish" @default.
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• W63821318 doi "https://doi.org/10.1016/b978-0-08-034186-6.50041-4" @default.
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