Matches in SemOpenAlex for { <https://semopenalex.org/work/W63854598> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W63854598 abstract "Glioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment.Immunohistochemically stained tissue sections have been microscopically analysed regarding immuno-reactive cells, cell proliferation, telomerase activity and presence of coxsackie adenovirus receptor (CAR). While telomerase activity reflects inherent life prolongation, CAR act as adhesion molecules on target cells in adenoviral based gene therapy.We found that cytotoxic T-lymfocytes (CTL) occurred spontaneously in GBM but also that a transient increase was detected after immunotherapy. Macrophage positive cells were in general plentiful.GBM as well as other grades of gliomas, expressed low levels of CAR while neuroblastomas and medulloblastomas exhibited a high CAR expression. However, various regions and cell types of the normal brain also expressed CAR.Proliferation activity (Ki-67) showed a significant correlation to longer survival if index was below 10 %, while telomerase activity (hTERT) showed no relation to length of survival. Different methods of assessment of Ki-67 are of relevance for histopathological diagnostics.This project indicates that morphological features of importance for prognosis and treatment can be identified by the use of established and simple, reliable methods, routinely applied in clinical pathological diagnostics." @default.
- W63854598 created "2016-06-24" @default.
- W63854598 creator A5017044730 @default.
- W63854598 date "2007-01-01" @default.
- W63854598 modified "2023-09-25" @default.
- W63854598 title "Glioblastoma multiforme in the microscope: Diagnostic features of importance for prognosis and treatment." @default.
- W63854598 hasPublicationYear "2007" @default.
- W63854598 type Work @default.
- W63854598 sameAs 63854598 @default.
- W63854598 citedByCount "0" @default.
- W63854598 crossrefType "dissertation" @default.
- W63854598 hasAuthorship W63854598A5017044730 @default.
- W63854598 hasConcept C104317684 @default.
- W63854598 hasConcept C125593758 @default.
- W63854598 hasConcept C142724271 @default.
- W63854598 hasConcept C147969180 @default.
- W63854598 hasConcept C154317977 @default.
- W63854598 hasConcept C167672396 @default.
- W63854598 hasConcept C202751555 @default.
- W63854598 hasConcept C203014093 @default.
- W63854598 hasConcept C204232928 @default.
- W63854598 hasConcept C207886595 @default.
- W63854598 hasConcept C2776194525 @default.
- W63854598 hasConcept C2777701055 @default.
- W63854598 hasConcept C2778227246 @default.
- W63854598 hasConcept C502942594 @default.
- W63854598 hasConcept C55493867 @default.
- W63854598 hasConcept C71924100 @default.
- W63854598 hasConcept C86803240 @default.
- W63854598 hasConcept C8891405 @default.
- W63854598 hasConcept C94581717 @default.
- W63854598 hasConceptScore W63854598C104317684 @default.
- W63854598 hasConceptScore W63854598C125593758 @default.
- W63854598 hasConceptScore W63854598C142724271 @default.
- W63854598 hasConceptScore W63854598C147969180 @default.
- W63854598 hasConceptScore W63854598C154317977 @default.
- W63854598 hasConceptScore W63854598C167672396 @default.
- W63854598 hasConceptScore W63854598C202751555 @default.
- W63854598 hasConceptScore W63854598C203014093 @default.
- W63854598 hasConceptScore W63854598C204232928 @default.
- W63854598 hasConceptScore W63854598C207886595 @default.
- W63854598 hasConceptScore W63854598C2776194525 @default.
- W63854598 hasConceptScore W63854598C2777701055 @default.
- W63854598 hasConceptScore W63854598C2778227246 @default.
- W63854598 hasConceptScore W63854598C502942594 @default.
- W63854598 hasConceptScore W63854598C55493867 @default.
- W63854598 hasConceptScore W63854598C71924100 @default.
- W63854598 hasConceptScore W63854598C86803240 @default.
- W63854598 hasConceptScore W63854598C8891405 @default.
- W63854598 hasConceptScore W63854598C94581717 @default.
- W63854598 hasLocation W638545981 @default.
- W63854598 hasOpenAccess W63854598 @default.
- W63854598 hasPrimaryLocation W638545981 @default.
- W63854598 hasRelatedWork W1621602741 @default.
- W63854598 hasRelatedWork W1983939718 @default.
- W63854598 hasRelatedWork W2000647838 @default.
- W63854598 hasRelatedWork W2018457522 @default.
- W63854598 hasRelatedWork W2040457951 @default.
- W63854598 hasRelatedWork W2042221269 @default.
- W63854598 hasRelatedWork W2051502825 @default.
- W63854598 hasRelatedWork W2063959580 @default.
- W63854598 hasRelatedWork W2069547392 @default.
- W63854598 hasRelatedWork W2089221119 @default.
- W63854598 hasRelatedWork W2104989233 @default.
- W63854598 hasRelatedWork W2140763084 @default.
- W63854598 hasRelatedWork W2154286839 @default.
- W63854598 hasRelatedWork W2238987237 @default.
- W63854598 hasRelatedWork W2324804857 @default.
- W63854598 hasRelatedWork W2354318198 @default.
- W63854598 hasRelatedWork W2404748883 @default.
- W63854598 hasRelatedWork W2428021229 @default.
- W63854598 hasRelatedWork W2515303689 @default.
- W63854598 hasRelatedWork W2914316259 @default.
- W63854598 isParatext "false" @default.
- W63854598 isRetracted "false" @default.
- W63854598 magId "63854598" @default.
- W63854598 workType "dissertation" @default.