Matches in SemOpenAlex for { <https://semopenalex.org/work/W63854747> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W63854747 endingPage "108.3" @default.
- W63854747 startingPage "108.3" @default.
- W63854747 abstract "Abstract RIG-I-like receptors (RLRs) are intracellular sensors utilized by nearly all cell types for recognition of viral RNA, initiation of antiviral defense, and induction of type I interferons (IFN). TBK1 is a critical kinase implicated in RLR-dependent IFN transcription. The E3 ligases Mind bomb 1 (MIB1) and Mind bomb 2 (MIB2) conjugate TBK1 with K63-linked polyubiquitin on residues K69 and K154. TBK1 polyubiquitination is critical for recruitment of the downstream adaptor, NEMO. After viral infection NEMO and IRF3 are independently recruited to MAVS. NEMO bridges TBK1 to MAVS through ubiquitin binding domains. The assembly of the NEMO/TBK1 complex on MAVS leads to activation of TBK1 kinase activity and phosphorylation of the transcription factor, IRF3. In contrast, activation of NF-kB is not impaired by MIB deficiency. The combined results refine current views of RLR signaling, define the role of TBK1 polyubiquitination and detail the assembly of the MAVS signalosome." @default.
- W63854747 created "2016-06-24" @default.
- W63854747 creator A5013283544 @default.
- W63854747 creator A5019713118 @default.
- W63854747 creator A5022473368 @default.
- W63854747 creator A5063856141 @default.
- W63854747 creator A5066121363 @default.
- W63854747 date "2012-05-01" @default.
- W63854747 modified "2023-10-15" @default.
- W63854747 title "NEMO recruitment of polyubiquitinated TBK1 to MAVS builds signalosome to regulate innate anti-viral immunity (108.3)" @default.
- W63854747 doi "https://doi.org/10.4049/jimmunol.188.supp.108.3" @default.
- W63854747 hasPublicationYear "2012" @default.
- W63854747 type Work @default.
- W63854747 sameAs 63854747 @default.
- W63854747 citedByCount "0" @default.
- W63854747 crossrefType "journal-article" @default.
- W63854747 hasAuthorship W63854747A5013283544 @default.
- W63854747 hasAuthorship W63854747A5019713118 @default.
- W63854747 hasAuthorship W63854747A5022473368 @default.
- W63854747 hasAuthorship W63854747A5063856141 @default.
- W63854747 hasAuthorship W63854747A5066121363 @default.
- W63854747 hasConcept C104317684 @default.
- W63854747 hasConcept C11960822 @default.
- W63854747 hasConcept C134459356 @default.
- W63854747 hasConcept C136449434 @default.
- W63854747 hasConcept C137361374 @default.
- W63854747 hasConcept C156155473 @default.
- W63854747 hasConcept C159047783 @default.
- W63854747 hasConcept C170493617 @default.
- W63854747 hasConcept C183786373 @default.
- W63854747 hasConcept C25602115 @default.
- W63854747 hasConcept C2780209191 @default.
- W63854747 hasConcept C54355233 @default.
- W63854747 hasConcept C86339819 @default.
- W63854747 hasConcept C86803240 @default.
- W63854747 hasConcept C95444343 @default.
- W63854747 hasConcept C97029542 @default.
- W63854747 hasConceptScore W63854747C104317684 @default.
- W63854747 hasConceptScore W63854747C11960822 @default.
- W63854747 hasConceptScore W63854747C134459356 @default.
- W63854747 hasConceptScore W63854747C136449434 @default.
- W63854747 hasConceptScore W63854747C137361374 @default.
- W63854747 hasConceptScore W63854747C156155473 @default.
- W63854747 hasConceptScore W63854747C159047783 @default.
- W63854747 hasConceptScore W63854747C170493617 @default.
- W63854747 hasConceptScore W63854747C183786373 @default.
- W63854747 hasConceptScore W63854747C25602115 @default.
- W63854747 hasConceptScore W63854747C2780209191 @default.
- W63854747 hasConceptScore W63854747C54355233 @default.
- W63854747 hasConceptScore W63854747C86339819 @default.
- W63854747 hasConceptScore W63854747C86803240 @default.
- W63854747 hasConceptScore W63854747C95444343 @default.
- W63854747 hasConceptScore W63854747C97029542 @default.
- W63854747 hasIssue "1_Supplement" @default.
- W63854747 hasLocation W638547471 @default.
- W63854747 hasOpenAccess W63854747 @default.
- W63854747 hasPrimaryLocation W638547471 @default.
- W63854747 hasRelatedWork W1999029823 @default.
- W63854747 hasRelatedWork W2005485591 @default.
- W63854747 hasRelatedWork W2047365750 @default.
- W63854747 hasRelatedWork W2063748622 @default.
- W63854747 hasRelatedWork W2132490889 @default.
- W63854747 hasRelatedWork W2537570544 @default.
- W63854747 hasRelatedWork W2804480350 @default.
- W63854747 hasRelatedWork W2971001314 @default.
- W63854747 hasRelatedWork W3016561449 @default.
- W63854747 hasRelatedWork W4311622391 @default.
- W63854747 hasVolume "188" @default.
- W63854747 isParatext "false" @default.
- W63854747 isRetracted "false" @default.
- W63854747 magId "63854747" @default.
- W63854747 workType "article" @default.