FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W638852016> ?p ?o ?g. }

• W638852016 endingPage "7" @default.
• W638852016 startingPage "1" @default.
• W638852016 abstract "Aside from its established immunologic and hematologic functions, the spleen also plays an important role in cardiovascular regulation. This occurs through changes in intrasplenic microvascular tone, as well as through splenic neurohormonal modulation of the renal and mesenteric vascular beds. Splenic regulation of blood volume occurs predominantly through fluid extravasation from the splenic circulation into lymphatic reservoirs; this is controlled by direct modulation of splenic pre- and postcapillary resistance by established physiologic agents such as atrial natriuretic peptide (ANP), nitric oxide (NO), and adrenomedullin (ADM). In addition to physiologic fluid regulation, splenic extravasation is a key factor in the inability to maintain adequate intravascular volume in septic shock. The spleen also controls renal microvascular tone through reflex activation of the splenic afferent and renal sympathetic nerves. This splenorenal reflex not only contributes to the physiologic regulation of blood pressure, but also contributes to the cardiovascular dysregulation associated with both septic shock and portal hypertension. In septic shock, the splenorenal reflex protectively limits splenic extravasation and potentially promotes renal sodium and water reabsorption and release of the vasoconstrictor angiotensin II; this function is eventually overwhelmed as shock progresses. In portal hypertension, on the other hand, the splenorenal reflex-mediated reduction in renal vascular conductance exacerbates sodium and water retention in the kidneys and may eventually contribute to renal dysfunction. Preliminary evidence suggests that the spleen also may play a role in the hemodynamic complications of portal hypertension via neurohormonal modulation of the mesenteric vascular bed. Lastly, the spleen itself may be a source of a vasoactive factor." @default.
• W638852016 created "2016-06-24" @default.
• W638852016 creator A5033746756 @default.
• W638852016 creator A5062981681 @default.
• W638852016 date "2009-01-01" @default.
• W638852016 modified "2023-10-18" @default.
• W638852016 title "Role of spleen in integrated control of splanchnic vascular tone: physiology and pathophysiologyThis article is part of a Special Issue on Information Transfer in the Microcirculation." @default.
• W638852016 cites W1603169425 @default.
• W638852016 cites W1970485224 @default.
• W638852016 cites W1972077634 @default.
• W638852016 cites W1979254004 @default.
• W638852016 cites W2003354393 @default.
• W638852016 cites W2004887716 @default.
• W638852016 cites W2006453324 @default.
• W638852016 cites W2009676145 @default.
• W638852016 cites W2014424879 @default.
• W638852016 cites W2018941298 @default.
• W638852016 cites W2024573458 @default.
• W638852016 cites W2036983784 @default.
• W638852016 cites W2044495035 @default.
• W638852016 cites W2051134261 @default.
• W638852016 cites W2052097767 @default.
• W638852016 cites W2053731747 @default.
• W638852016 cites W2053814268 @default.
• W638852016 cites W2055117944 @default.
• W638852016 cites W2070001306 @default.
• W638852016 cites W2075537226 @default.
• W638852016 cites W2079856187 @default.
• W638852016 cites W2085209885 @default.
• W638852016 cites W2086272550 @default.
• W638852016 cites W2095552108 @default.
• W638852016 cites W2096320400 @default.
• W638852016 cites W2115257463 @default.
• W638852016 cites W2126531130 @default.
• W638852016 cites W2128592505 @default.
• W638852016 cites W2141970649 @default.
• W638852016 cites W2142084399 @default.
• W638852016 cites W2142349652 @default.
• W638852016 cites W2142773071 @default.
• W638852016 cites W2149635908 @default.
• W638852016 cites W2150440782 @default.
• W638852016 cites W2154476968 @default.
• W638852016 cites W2181472621 @default.
• W638852016 cites W2287647043 @default.
• W638852016 cites W4248385196 @default.
• W638852016 doi "https://doi.org/10.1139/y08-103" @default.
• W638852016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19142210" @default.
• W638852016 hasPublicationYear "2009" @default.
• W638852016 type Work @default.
• W638852016 sameAs 638852016 @default.
• W638852016 citedByCount "41" @default.
• W638852016 countsByYear W6388520162012 @default.
• W638852016 countsByYear W6388520162013 @default.
• W638852016 countsByYear W6388520162014 @default.
• W638852016 countsByYear W6388520162015 @default.
• W638852016 countsByYear W6388520162016 @default.
• W638852016 countsByYear W6388520162017 @default.
• W638852016 countsByYear W6388520162018 @default.
• W638852016 countsByYear W6388520162019 @default.
• W638852016 countsByYear W6388520162020 @default.
• W638852016 countsByYear W6388520162022 @default.
• W638852016 countsByYear W6388520162023 @default.
• W638852016 crossrefType "journal-article" @default.
• W638852016 hasAuthorship W638852016A5033746756 @default.
• W638852016 hasAuthorship W638852016A5062981681 @default.
• W638852016 hasConcept C126322002 @default.
• W638852016 hasConcept C134018914 @default.
• W638852016 hasConcept C142724271 @default.
• W638852016 hasConcept C2777214474 @default.
• W638852016 hasConcept C2777628635 @default.
• W638852016 hasConcept C2778384902 @default.
• W638852016 hasConcept C2778808290 @default.
• W638852016 hasConcept C2779540182 @default.
• W638852016 hasConcept C2780091579 @default.
• W638852016 hasConcept C2780931953 @default.
• W638852016 hasConcept C2781300812 @default.
• W638852016 hasConcept C58245268 @default.
• W638852016 hasConcept C71924100 @default.
• W638852016 hasConcept C84393581 @default.
• W638852016 hasConceptScore W638852016C126322002 @default.
• W638852016 hasConceptScore W638852016C134018914 @default.
• W638852016 hasConceptScore W638852016C142724271 @default.
• W638852016 hasConceptScore W638852016C2777214474 @default.
• W638852016 hasConceptScore W638852016C2777628635 @default.
• W638852016 hasConceptScore W638852016C2778384902 @default.
• W638852016 hasConceptScore W638852016C2778808290 @default.
• W638852016 hasConceptScore W638852016C2779540182 @default.
• W638852016 hasConceptScore W638852016C2780091579 @default.
• W638852016 hasConceptScore W638852016C2780931953 @default.
• W638852016 hasConceptScore W638852016C2781300812 @default.
• W638852016 hasConceptScore W638852016C58245268 @default.
• W638852016 hasConceptScore W638852016C71924100 @default.
• W638852016 hasConceptScore W638852016C84393581 @default.
• W638852016 hasIssue "1" @default.
• W638852016 hasLocation W6388520161 @default.
• W638852016 hasLocation W6388520162 @default.
• W638852016 hasOpenAccess W638852016 @default.
• W638852016 hasPrimaryLocation W6388520161 @default.

• next