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• W63894966 abstract "Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes." @default.
• W63894966 created "2016-06-24" @default.
• W63894966 creator A5051396652 @default.
• W63894966 creator A5063253432 @default.
• W63894966 date "2007-06-25" @default.
• W63894966 modified "2023-09-27" @default.
• W63894966 title "Regulation of pancreatic beta-cell function by adipocytes." @default.
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• W63894966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17579776" @default.
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