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- W639138518 abstract "目的：探讨脂脉宁抗动脉粥样硬化（AS）的作用机制。方法：用高脂饲料复制家兔AS模型,于4周后再灌服脂脉宁4周,检测血脂、氧化指标及主动脉低密度脂蛋白受体（LDL-R）mRNA及血管细胞黏附分子-1（VCAM-1）mRNA的表达。结果：模型组血脂4项及超氧化物歧化酶（SOD）、丙二醛（MDA）均明显较空白组升高,谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH-Px）降低,主动脉内膜、斑块明显增厚;脂脉宁0.375,0.188 g.kg-1血脂及MDA含量均明显较模型组降低,GSH,GSH-Px升高,动脉斑块减小,高剂量组效果更明显。模型组LDL-R mRNA表达明显降低,VCAM-1 mRNA表达升高;给药2组LDL-RmRNA表达则明显升高,VCAM-1 mRNA表达降低,高剂量组尤为明显。结论：脂脉宁抗AS作用与其调整脂质代谢、抗氧化及调控LDL-R mRNA及VCAM-1 mRNA表达有关。" @default.
- W639138518 created "2016-06-24" @default.
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- W639138518 date "2011-01-01" @default.
- W639138518 modified "2023-09-24" @default.
- W639138518 title "脂脉宁对动脉粥样硬化家兔氧化应激反应及LDL-R,VCAM-1基因表达的影响" @default.
- W639138518 hasPublicationYear "2011" @default.
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