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- W63963223 abstract "The classic animal model for induction of graft-versus-host reactions (GVHRs) [1] is the parent → F1 hybrid system (Fig. 1). A variety of different pathologic lesions can be induced in this system, as has recently been reviewed in great detail [28, 54]. In the present article, we shall focus on a pathogenetic concept of lymphomagenesis and autoimmunization which was prompted on the one hand by experiments performed with GVH model and on the other hand by important recent discoveries concerning the physiologic reactions of T-lymphocytes to structures of the major histocompatibility complex (MHC). Since T-cell anti-MHC reactions that are comparable to those seen during the GVHR may also occur in an autologous system (i.e., between the cells of the same individual), it has been postulated that they may lead to the same diseases as in the semiallogeneic parent → F1 hybrid system [49, 54]. This hypothesis will be reexamined in the light of recent findings obtained by several groups of investigators." @default.
- W63963223 created "2016-06-24" @default.
- W63963223 creator A5022831162 @default.
- W63963223 creator A5076926945 @default.
- W63963223 creator A5091573203 @default.
- W63963223 date "1978-01-01" @default.
- W63963223 modified "2023-09-25" @default.
- W63963223 title "Lymphomagenesis and Autoimmunization Caused by Reactions of T-Lymphocytes to Incompatible Structures of the Major Histocompatibility Complex: A Concept of Pathogenesis" @default.
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