Matches in SemOpenAlex for { <https://semopenalex.org/work/W64009767> ?p ?o ?g. }
- W64009767 endingPage "125" @default.
- W64009767 startingPage "91" @default.
- W64009767 abstract "This chapter describes the evidence that suggests alterations in the ability of neurons to properly regulate calcium dynamics. These contribute to the normal age-related dysfunction of the nervous system and to the pathogenesis of neurodegenerative disorders. The calcium ion is the most important intracellular messenger in the brain, playing pivotal roles in neuronal development, synaptic transmission and plasticity, and the regulation of various metabolic pathways. Alterations in cellular calcium homeostasis occur in brain cells during aging and may contribute to age-related deficits in sensory and motor functions and cognition. Abnormalities in specific calcium-regulating systems have been documented in neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and stroke. Altered proteolytic processing of the amyloid precursor protein (APP) results in increased production of amyloid β-peptide. It forms insoluble aggregates and induces oxidative stress in neurons that impairs ion homeostasis and energy metabolism resulting in synaptic dysfunction and increased vulnerability of neurons to apoptosis and excitotoxicity. This regulation of cellular calcium homeostasis may trigger a process of programmed cell death called “apoptosis,” which is now strongly implicated in age-related neurodegenerative disorders." @default.
- W64009767 created "2016-06-24" @default.
- W64009767 creator A5011004935 @default.
- W64009767 creator A5083040475 @default.
- W64009767 date "2002-01-01" @default.
- W64009767 modified "2023-09-25" @default.
- W64009767 title "Chapter 6 Calcium and the pathogenesis of neurodegenerative disorders" @default.
- W64009767 cites W1429380639 @default.
- W64009767 cites W1486617476 @default.
- W64009767 cites W1487350256 @default.
- W64009767 cites W1488124756 @default.
- W64009767 cites W1497413049 @default.
- W64009767 cites W1504584187 @default.
- W64009767 cites W1507112934 @default.
- W64009767 cites W1520542863 @default.
- W64009767 cites W1529024588 @default.
- W64009767 cites W1531415074 @default.
- W64009767 cites W1566528879 @default.
- W64009767 cites W1596063778 @default.
- W64009767 cites W1611341694 @default.
- W64009767 cites W1622978237 @default.
- W64009767 cites W1626267121 @default.
- W64009767 cites W1647600194 @default.
- W64009767 cites W1674757660 @default.
- W64009767 cites W1675105744 @default.
- W64009767 cites W1693283493 @default.
- W64009767 cites W1718709781 @default.
- W64009767 cites W1762207349 @default.
- W64009767 cites W1778519373 @default.
- W64009767 cites W1806089348 @default.
- W64009767 cites W1830456158 @default.
- W64009767 cites W1838431443 @default.
- W64009767 cites W1838634581 @default.
- W64009767 cites W1877873625 @default.
- W64009767 cites W1886575365 @default.
- W64009767 cites W1889533143 @default.
- W64009767 cites W1900066504 @default.
- W64009767 cites W1945836171 @default.
- W64009767 cites W1948681014 @default.
- W64009767 cites W1950983788 @default.
- W64009767 cites W1964780858 @default.
- W64009767 cites W1965123366 @default.
- W64009767 cites W1965828206 @default.
- W64009767 cites W1968151995 @default.
- W64009767 cites W1969358264 @default.
- W64009767 cites W1969455851 @default.
- W64009767 cites W1970293512 @default.
- W64009767 cites W1970846389 @default.
- W64009767 cites W1973383950 @default.
- W64009767 cites W1974434762 @default.
- W64009767 cites W1974545879 @default.
- W64009767 cites W1977237836 @default.
- W64009767 cites W1978874104 @default.
- W64009767 cites W1978887177 @default.
- W64009767 cites W1979402156 @default.
- W64009767 cites W1979545106 @default.
- W64009767 cites W1979886157 @default.
- W64009767 cites W1980480637 @default.
- W64009767 cites W1984098639 @default.
- W64009767 cites W1985143687 @default.
- W64009767 cites W1985859760 @default.
- W64009767 cites W1986403068 @default.
- W64009767 cites W1987510933 @default.
- W64009767 cites W1987733177 @default.
- W64009767 cites W1987885884 @default.
- W64009767 cites W1990764244 @default.
- W64009767 cites W1991951855 @default.
- W64009767 cites W1992673078 @default.
- W64009767 cites W1994739050 @default.
- W64009767 cites W1995095791 @default.
- W64009767 cites W1995188451 @default.
- W64009767 cites W1995843335 @default.
- W64009767 cites W1996305854 @default.
- W64009767 cites W1997197588 @default.
- W64009767 cites W1999037077 @default.
- W64009767 cites W2001210466 @default.
- W64009767 cites W2003148573 @default.
- W64009767 cites W2006388911 @default.
- W64009767 cites W2007890001 @default.
- W64009767 cites W2012264825 @default.
- W64009767 cites W2012592399 @default.
- W64009767 cites W2013309566 @default.
- W64009767 cites W2013486761 @default.
- W64009767 cites W2013629772 @default.
- W64009767 cites W2014094971 @default.
- W64009767 cites W2014163855 @default.
- W64009767 cites W2015026638 @default.
- W64009767 cites W2015697266 @default.
- W64009767 cites W2016807756 @default.
- W64009767 cites W2016973061 @default.
- W64009767 cites W2019917942 @default.
- W64009767 cites W2020318455 @default.
- W64009767 cites W2021387901 @default.
- W64009767 cites W2023115254 @default.
- W64009767 cites W2024555862 @default.
- W64009767 cites W2025242397 @default.
- W64009767 cites W2025386054 @default.
- W64009767 cites W2026410063 @default.