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- W64010341 abstract "In this study we investigated the effect of early life conditioning (hypoxia ± hypercapnia) on adult acute ventilatory sensitivity to hypoxia and hypercapnia. Mice were exposed to either hypoxia (5% O(2)) or hypoxia/hypercapnia (5% O(2)/8% CO(2)) in a normobaric chamber for 2 h at postnatal day 2 (P2), and then returned to normoxia. At 3 months of age, hypoxic ventilatory response (HVR) and hypercapnic ventilatory response (HCVR) were measured using a plethysmograph system. Results showed that HVR was significantly decreased in the P2-hypoxia mice but not in the P2 hypoxia/hypercapnia mice as compared to the P2-normoxic mice, respectively. However, HCVR was significantly decreased in the P2 hypoxia-hypercapnia group but not in the P2-hypoxia group. These data suggest early postnatal hypoxic stress vs. hypoxic/hypercapnic stress plays different roles in fetal programming of the respiratory control system as shown by altered adult acute ventilatory sensitivity." @default.
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- W64010341 date "2018-01-01" @default.
- W64010341 modified "2023-09-23" @default.
- W64010341 title "Erratum to: Early Life Hypoxic or Hypoxic/Hypercapnic Stress Alters Acute Ventilatory Sensitivity in Adult Mice" @default.
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- W64010341 doi "https://doi.org/10.1007/978-1-4614-4989-8_54" @default.
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