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- W640402914 abstract "In earlier studies it was shown that synthetic and chemically well-defined Dnp-oligolysines did induce both cellular and humoral immunity in guinea pigs, and that this response was under immune response gene control (1, 2). Sera of guinea pigs of genetic responder strain immunized with synthetic Dnp-oligolysine peptides have been shown to contain highly specific antibodies of restricted heterogeneity which could discriminate Dnp-oligolysines with minimal changes in hapten position, chain length, D-lysine-alanine sub-stituents (3–7). Like specificity has been shown in T-cell responses of responder guinea pigs to these simple antigens since they could also discriminate equally well the homologous immunizing antigen from closely related ones in assays measuring antigen-induced delayed hypersensitivity, tritiated thymidine incorporation, and mediator production (8–9). Non-responder animals, in contrast, lack a T-cell response to these antigens and the antibody produced in the absence of T-cells, while Dnp-specific, could not discriminate one Dnp-oligopeptide from another (6). Exquisite specificity of antibody in animals with highly specific T-cell responses and the lack of it in non-responder guinea pigs immunized to the same antigen suggested that T-cells could select specific B-cell clones to proliferate (10). To test this possibility, studies were undertaken to explore antigen-induced B-cell responses in both strain 2 and 13 guinea pigs in the presence and absence of Dnp-oligolysine-specific T-cells. These experiments will emphasize the role of specific T-cells in the selection and amplification of unique B-cell clones." @default.
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- W640402914 date "1978-01-01" @default.
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- W640402914 title "T-Cell Regulation of Restricted B-Cell Responses" @default.
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- W640402914 doi "https://doi.org/10.1007/978-1-4615-8858-0_23" @default.
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