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- W6404082 abstract "Introduction: Sarcoplasmic reticulum (SR) Ca2+ leak activates the inward Na+-Ca2+ exchange current (INCX) causing delayed afterdepolarsations (DADs) that promote arrhythmias. Whether this mechanism contributes to promotion of atrial fibrillation (AF) is unknown and was the object of this study. Methods: Membrane currents and potentials (patch clamp) and [Ca2+]i (Fluo-3) were measured in right-atrial myocytes from sinus rhythm (Ctl) or chronic AF (cAF) patients. Tetracaine (1 mM) or single-channel recordings were used to quantify SR Ca2+ leak through ryanodine-receptor channels (RyR2). Proteins were measured by immunoblotting. Results: Diastolic [Ca2+]i and SR Ca2+ content (integrated INCX during caffeine-induced [Ca2+]i transient [cCaT]) were unchanged, whereas diastolic SR Ca2+ leak was ∼50% higher in cAF than in Ctl (Figure). Calmodulin expression (+60%), CaMKII autophosphorylation (activation) at Thr287 (+40%) and Ser2808-phosphorylation (PKA/CaMKII-site) of RyR2 (+250%) were higher in cAF than in Ctl...." @default.
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- W6404082 date "2010-11-23" @default.
- W6404082 modified "2023-09-27" @default.
- W6404082 title "Abstract 16909: Sarcoplasmic Reticulum Calcium Leak and Enhanced NCX Increase Occurrence of Delayed Afterdepolarisations in Atrial Myocytes from Patients with Chronic Atrial Fibrillation" @default.
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