Matches in SemOpenAlex for { <https://semopenalex.org/work/W640716098> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W640716098 abstract "Introduction: Cardiac transthyretin (ATTR) amyloidosis is an increasingly diagnosed cause of heart failure. Wild-type ATTR amyloidosis (ATTRwt) is a disease of older Caucasian men. Hereditary (mutant) cardiac ATTR amyloidosis (ATTRm) is most commonly associated with the V122I transthyretin (TTR) variant carried by 3-4% of African Americans or the T60A TTR variant in patients of Irish ancestry, the latter presenting with a mixed cardiac and neurologic phenotype. Most published data consider electrocardiographic (ECG) findings in ATTR amyloidosis as a single entity. Prognostic factors for survival in cardiac ATTR amyloidosis are poorly defined. Methods and Results: We analysed ECGs from 158 patients with cardiac ATTR amyloidosis (ATTRwt=75; V122I=49; T60A=34) in a longitudinal retrospective study. Results are shown in Table 1. 63 patients died; 29 ATTRwt, 24 V122I, 10 T60A, during follow-up of 22.7±14.6, 23.8±12.8, and 31.3±20.4 months respectively. Overall median survival: ATTRwt 3.1yr (95%CI:2.2-4.0); V122I 2.6 yr (95%CI:2.2-3.0); T60A not reached. In ATTRwt, broad QRS (≥120ms) was associated with worse survival (1.6yr; 95%CI:1.3-1.9 vs not reached). No other ECG parameter in ATTRwt, and none in either ATTRm group affected survival. On univariate analysis of the ATTRwt cohort, broad QRS, age, systolic BP, TropT and NTproBNP were significant variables at the <1% level, and eGFR at the 5% level; LVEF, septal S’ TDI and global longitudinal strain were not significant. On multivariate analysis only broad QRS (HR: 3.0, CI 1.2-7.5; P=0.024) and NTproBNP (HR: 3.0, CI 1.1-7.4; P=0.026) predicted mortality. Among ATTRwt patients, there were no significant differences of other characteristics between those with narrow and those with broad QRS complexes. Conclusions: The ECG in cardiac ATTR amyloidosis is heterogeneous, greater awareness of which might help prevent diagnostic delays. Broad QRS complexes and NTproBNP are independent predictors of mortality in ATTRwt." @default.
- W640716098 created "2016-06-24" @default.
- W640716098 creator A5020344924 @default.
- W640716098 creator A5033490022 @default.
- W640716098 creator A5043019926 @default.
- W640716098 creator A5050125018 @default.
- W640716098 creator A5057365396 @default.
- W640716098 creator A5061857871 @default.
- W640716098 creator A5067575233 @default.
- W640716098 creator A5070082694 @default.
- W640716098 creator A5088526711 @default.
- W640716098 date "2014-11-25" @default.
- W640716098 modified "2023-09-27" @default.
- W640716098 title "Abstract 16030: Heterogeneity of Electrocardiographic Findings in Cardiac Transthyretin (ATTR) Amyloidosis and Impact on Survival" @default.
- W640716098 doi "https://doi.org/10.1161/circ.130.suppl_2.16030" @default.
- W640716098 hasPublicationYear "2014" @default.
- W640716098 type Work @default.
- W640716098 sameAs 640716098 @default.
- W640716098 citedByCount "1" @default.
- W640716098 countsByYear W6407160982015 @default.
- W640716098 crossrefType "journal-article" @default.
- W640716098 hasAuthorship W640716098A5020344924 @default.
- W640716098 hasAuthorship W640716098A5033490022 @default.
- W640716098 hasAuthorship W640716098A5043019926 @default.
- W640716098 hasAuthorship W640716098A5050125018 @default.
- W640716098 hasAuthorship W640716098A5057365396 @default.
- W640716098 hasAuthorship W640716098A5061857871 @default.
- W640716098 hasAuthorship W640716098A5067575233 @default.
- W640716098 hasAuthorship W640716098A5070082694 @default.
- W640716098 hasAuthorship W640716098A5088526711 @default.
- W640716098 hasConcept C111773187 @default.
- W640716098 hasConcept C121157162 @default.
- W640716098 hasConcept C126322002 @default.
- W640716098 hasConcept C164705383 @default.
- W640716098 hasConcept C2777607188 @default.
- W640716098 hasConcept C2778198053 @default.
- W640716098 hasConcept C2779951007 @default.
- W640716098 hasConcept C71924100 @default.
- W640716098 hasConcept C72563966 @default.
- W640716098 hasConceptScore W640716098C111773187 @default.
- W640716098 hasConceptScore W640716098C121157162 @default.
- W640716098 hasConceptScore W640716098C126322002 @default.
- W640716098 hasConceptScore W640716098C164705383 @default.
- W640716098 hasConceptScore W640716098C2777607188 @default.
- W640716098 hasConceptScore W640716098C2778198053 @default.
- W640716098 hasConceptScore W640716098C2779951007 @default.
- W640716098 hasConceptScore W640716098C71924100 @default.
- W640716098 hasConceptScore W640716098C72563966 @default.
- W640716098 hasIssue "suppl_2" @default.
- W640716098 hasLocation W6407160981 @default.
- W640716098 hasOpenAccess W640716098 @default.
- W640716098 hasPrimaryLocation W6407160981 @default.
- W640716098 hasRelatedWork W1831021936 @default.
- W640716098 hasRelatedWork W2004801645 @default.
- W640716098 hasRelatedWork W2163584170 @default.
- W640716098 hasRelatedWork W2169965998 @default.
- W640716098 hasRelatedWork W2507912906 @default.
- W640716098 hasRelatedWork W2509971241 @default.
- W640716098 hasRelatedWork W2522369925 @default.
- W640716098 hasRelatedWork W2763137140 @default.
- W640716098 hasRelatedWork W2808969900 @default.
- W640716098 hasRelatedWork W2937755845 @default.
- W640716098 hasRelatedWork W2947295952 @default.
- W640716098 hasRelatedWork W2973082005 @default.
- W640716098 hasRelatedWork W3025691850 @default.
- W640716098 hasRelatedWork W3046896574 @default.
- W640716098 hasRelatedWork W3091008461 @default.
- W640716098 hasRelatedWork W3091086821 @default.
- W640716098 hasRelatedWork W3106641441 @default.
- W640716098 hasRelatedWork W3178371503 @default.
- W640716098 hasRelatedWork W3192578459 @default.
- W640716098 hasRelatedWork W3210326233 @default.
- W640716098 hasVolume "130" @default.
- W640716098 isParatext "false" @default.
- W640716098 isRetracted "false" @default.
- W640716098 magId "640716098" @default.
- W640716098 workType "article" @default.