Matches in SemOpenAlex for { <https://semopenalex.org/work/W640838149> ?p ?o ?g. }
- W640838149 endingPage "45" @default.
- W640838149 startingPage "39" @default.
- W640838149 abstract "Exposure to environmental chemicals, including phthalates and phenols such as parabens and triclosan, is ubiquitous within the U.S. general population.This proof-of-concept rodent study examined the relationship between oral doses of three widely used personal care product ingredients [diethyl phthalate (DEP), methyl paraben (MPB), and triclosan] and urine and serum concentrations of their respective biomarkers.Using female Sprague-Dawley rats, we carried out two rounds of experiments with oral gavage doses selected in accordance with no observed adverse effect levels (NOAELs) derived from previous studies: 1,735 (DEP), 1,050 (MPB), 50 (triclosan) mg/kg/day. Administered doses ranged from 0.005 to 173 mg/kg/day, 10-100,000 times below the NOAEL for each chemical. Controls for the MPB and triclosan experiments were animals treated with olive oil (vehicle) only; controls for the DEP serum experiments were animals treated with the lowest doses of MPB and triclosan. Doses were administered for 5 days with five rats in each treatment group. Urine and blood serum, collected on the last day of exposure, were analyzed for biomarkers. Relationships between oral dose and biomarker concentrations were assessed using linear regression.Biomarkers were detected in all control urine samples at parts-per-billion levels, suggesting a low endemic environmental exposure to the three chemicals that could not be controlled even with all of the precautionary measures undertaken. Among the exposed animals, urinary concentrations of all three biomarkers were orders of magnitude higher than those in serum. A consistently positive linear relationship between oral dose and urinary concentration was observed (R2 > 0.80); this relationship was inconsistent in serum.Our study highlights the importance of carefully considering the oral dose used in animal experiments and provides useful information in selecting doses for future studies.Teitelbaum SL, Li Q, Lambertini L, Belpoggi F, Manservisi F, Falcioni L, Bua L, Silva MJ, Ye X, Calafat AM, Chen J. 2016. Paired serum and urine concentrations of biomarkers of diethyl phthalate, methyl paraben, and triclosan in rats. Environ Health Perspect 124:39-45; http://dx.doi.org/10.1289/ehp.1409586." @default.
- W640838149 created "2016-06-24" @default.
- W640838149 creator A5008600653 @default.
- W640838149 creator A5014942240 @default.
- W640838149 creator A5015242677 @default.
- W640838149 creator A5029868654 @default.
- W640838149 creator A5035350588 @default.
- W640838149 creator A5057311183 @default.
- W640838149 creator A5058576259 @default.
- W640838149 creator A5061130250 @default.
- W640838149 creator A5074913777 @default.
- W640838149 creator A5079448339 @default.
- W640838149 creator A5083227205 @default.
- W640838149 date "2016-01-01" @default.
- W640838149 modified "2023-09-30" @default.
- W640838149 title "Paired Serum and Urine Concentrations of Biomarkers of Diethyl Phthalate, Methyl Paraben, and Triclosan in Rats" @default.
- W640838149 cites W1964239883 @default.
- W640838149 cites W1968925582 @default.
- W640838149 cites W1971820910 @default.
- W640838149 cites W1977604459 @default.
- W640838149 cites W1979232857 @default.
- W640838149 cites W1981363323 @default.
- W640838149 cites W1982139221 @default.
- W640838149 cites W1986053132 @default.
- W640838149 cites W1986721037 @default.
- W640838149 cites W1987012783 @default.
- W640838149 cites W1988565626 @default.
- W640838149 cites W1998248480 @default.
- W640838149 cites W2002138184 @default.
- W640838149 cites W2009553946 @default.
- W640838149 cites W2012769387 @default.
- W640838149 cites W2016069630 @default.
- W640838149 cites W2019913219 @default.
- W640838149 cites W2027021333 @default.
- W640838149 cites W2030212644 @default.
- W640838149 cites W2053594689 @default.
- W640838149 cites W2056946947 @default.
- W640838149 cites W2058759573 @default.
- W640838149 cites W2070754900 @default.
- W640838149 cites W2070823218 @default.
- W640838149 cites W2071616652 @default.
- W640838149 cites W2073686452 @default.
- W640838149 cites W2078798476 @default.
- W640838149 cites W2079538975 @default.
- W640838149 cites W2080735446 @default.
- W640838149 cites W2083310900 @default.
- W640838149 cites W2085022232 @default.
- W640838149 cites W2085157922 @default.
- W640838149 cites W2085253349 @default.
- W640838149 cites W2090092358 @default.
- W640838149 cites W2094071196 @default.
- W640838149 cites W2094218749 @default.
- W640838149 cites W2096209528 @default.
- W640838149 cites W2097327668 @default.
- W640838149 cites W2106317719 @default.
- W640838149 cites W2108166727 @default.
- W640838149 cites W2117897211 @default.
- W640838149 cites W2120543755 @default.
- W640838149 cites W2128685723 @default.
- W640838149 cites W2130742854 @default.
- W640838149 cites W2133461377 @default.
- W640838149 cites W2137766269 @default.
- W640838149 cites W2150227280 @default.
- W640838149 cites W2150239640 @default.
- W640838149 cites W2151589819 @default.
- W640838149 cites W2157368519 @default.
- W640838149 cites W2160705379 @default.
- W640838149 cites W2165700542 @default.
- W640838149 cites W2166306372 @default.
- W640838149 cites W2169101393 @default.
- W640838149 cites W2171015613 @default.
- W640838149 cites W2322758683 @default.
- W640838149 doi "https://doi.org/10.1289/ehp.1409586" @default.
- W640838149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4710607" @default.
- W640838149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26047088" @default.
- W640838149 hasPublicationYear "2016" @default.
- W640838149 type Work @default.
- W640838149 sameAs 640838149 @default.
- W640838149 citedByCount "18" @default.
- W640838149 countsByYear W6408381492016 @default.
- W640838149 countsByYear W6408381492017 @default.
- W640838149 countsByYear W6408381492018 @default.
- W640838149 countsByYear W6408381492019 @default.
- W640838149 countsByYear W6408381492020 @default.
- W640838149 countsByYear W6408381492021 @default.
- W640838149 countsByYear W6408381492023 @default.
- W640838149 crossrefType "journal-article" @default.
- W640838149 hasAuthorship W640838149A5008600653 @default.
- W640838149 hasAuthorship W640838149A5014942240 @default.
- W640838149 hasAuthorship W640838149A5015242677 @default.
- W640838149 hasAuthorship W640838149A5029868654 @default.
- W640838149 hasAuthorship W640838149A5035350588 @default.
- W640838149 hasAuthorship W640838149A5057311183 @default.
- W640838149 hasAuthorship W640838149A5058576259 @default.
- W640838149 hasAuthorship W640838149A5061130250 @default.
- W640838149 hasAuthorship W640838149A5074913777 @default.
- W640838149 hasAuthorship W640838149A5079448339 @default.
- W640838149 hasAuthorship W640838149A5083227205 @default.