FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W640924987> ?p ?o ?g. }

• W640924987 abstract "Angiotensin converting enzyme (ACE) inhibitors lisinopril and ramipril were selected from EMA/480197/2010 and the potassium-sparing diuretic spironolactone was selected from the NHS specials list for November 2011 drug tariff with the view to produce oral liquid formulations providing dosage forms targeting paediatrics. Lisinopril, ramipril and spironolactone were chosen for their interaction with transporter proteins in the small intestine. Formulation limitations such as poor solubility or pH sensitivity needed consideration. Lisinopril was formulated without extensive development as drug and excipients were water soluble. Ramipril and spironolactone are both insoluble in water and strategies combating this were employed. Ramipril was successfully solubilised using low concentrations of acetic acid in a co-solvent system and also via complexation with hydroxypropyl-β-cyclodextrin. A ramipril suspension was produced to take formulation development in a third direction. Spironolactone dosages were too high for solubilisation techniques to be effective so suspensions were developed. A buffer controlled pH for the sensitive drug whilst a precisely balanced surfactant and suspending agent mix provided excellent physical stability. Characterisation, stability profiling and permeability assessment were performed following formulation development. The formulation process highlighted current shortcomings in techniques for taste assessment of pharmaceutical preparations resulting in early stage research into a novel in vitro cell based assay. The formulations developed in the initial phase of the research were used as model formulations investigating microarray application in an in vitro-in vivo correlation for carrier mediated drug absorption. Caco-2 cells were assessed following transport studies for changes in genetic expression of the ATP-binding cassette and solute carrier transporter superfamilies. Findings of which were compared to in vitro and in vivo permeability findings. It was not possible to ascertain a correlation between in vivo drug absorption and the expression of individual genes or even gene families, however there was a correlation (R2 = 0.9934) between the total number of genes with significantly changed expression levels and the predicted human absorption." @default.
• W640924987 created "2016-06-24" @default.
• W640924987 creator A5075437204 @default.
• W640924987 date "2014-12-18" @default.
• W640924987 modified "2023-09-25" @default.
• W640924987 title "Paediatric drug development: reformulation, in vitro, genomic and in vivo evaluation" @default.
• W640924987 cites W1503426215 @default.
• W640924987 cites W1538704317 @default.
• W640924987 cites W1664312070 @default.
• W640924987 cites W1740107533 @default.
• W640924987 cites W1755208670 @default.
• W640924987 cites W1961583428 @default.
• W640924987 cites W1965222198 @default.
• W640924987 cites W1965957666 @default.
• W640924987 cites W1967737783 @default.
• W640924987 cites W1970156673 @default.
• W640924987 cites W1970763749 @default.
• W640924987 cites W1974109301 @default.
• W640924987 cites W1975336358 @default.
• W640924987 cites W1975635279 @default.
• W640924987 cites W1976208596 @default.
• W640924987 cites W1976943394 @default.
• W640924987 cites W1977034851 @default.
• W640924987 cites W1980207776 @default.
• W640924987 cites W1987676465 @default.
• W640924987 cites W1988967653 @default.
• W640924987 cites W1989482499 @default.
• W640924987 cites W1997492372 @default.
• W640924987 cites W2000447210 @default.
• W640924987 cites W2004078982 @default.
• W640924987 cites W2006434892 @default.
• W640924987 cites W2007788734 @default.
• W640924987 cites W2009899562 @default.
• W640924987 cites W2010104618 @default.
• W640924987 cites W2012557331 @default.
• W640924987 cites W2014448809 @default.
• W640924987 cites W2018979823 @default.
• W640924987 cites W2026738793 @default.
• W640924987 cites W2028047186 @default.
• W640924987 cites W2028533496 @default.
• W640924987 cites W2029364498 @default.
• W640924987 cites W2038746573 @default.
• W640924987 cites W2041725964 @default.
• W640924987 cites W2041747627 @default.
• W640924987 cites W2044773944 @default.
• W640924987 cites W2045167141 @default.
• W640924987 cites W2047085682 @default.
• W640924987 cites W2048859084 @default.
• W640924987 cites W2050349935 @default.
• W640924987 cites W2051312790 @default.
• W640924987 cites W2055924197 @default.
• W640924987 cites W2057299821 @default.
• W640924987 cites W2060988580 @default.
• W640924987 cites W2062941476 @default.
• W640924987 cites W2067468321 @default.
• W640924987 cites W2067813406 @default.
• W640924987 cites W2068877219 @default.
• W640924987 cites W2070114955 @default.
• W640924987 cites W2073394985 @default.
• W640924987 cites W2073989889 @default.
• W640924987 cites W2074582913 @default.
• W640924987 cites W2074927293 @default.
• W640924987 cites W2076096613 @default.
• W640924987 cites W2077460068 @default.
• W640924987 cites W2086474578 @default.
• W640924987 cites W2086498492 @default.
• W640924987 cites W2087526440 @default.
• W640924987 cites W2090966844 @default.
• W640924987 cites W2092045975 @default.
• W640924987 cites W2092256487 @default.
• W640924987 cites W2093500966 @default.
• W640924987 cites W2095830677 @default.
• W640924987 cites W2097088760 @default.
• W640924987 cites W2100358013 @default.
• W640924987 cites W2102443458 @default.
• W640924987 cites W2104283436 @default.
• W640924987 cites W2105762439 @default.
• W640924987 cites W2107406250 @default.
• W640924987 cites W2110095303 @default.
• W640924987 cites W2112093679 @default.
• W640924987 cites W2113310577 @default.
• W640924987 cites W2114374597 @default.
• W640924987 cites W2117395768 @default.
• W640924987 cites W2120455859 @default.
• W640924987 cites W2120694471 @default.
• W640924987 cites W2135732933 @default.
• W640924987 cites W2136868488 @default.
• W640924987 cites W2138970551 @default.
• W640924987 cites W2142132359 @default.
• W640924987 cites W2142191800 @default.
• W640924987 cites W2145064491 @default.
• W640924987 cites W2151272989 @default.
• W640924987 cites W2153114697 @default.
• W640924987 cites W2156398303 @default.
• W640924987 cites W2157970175 @default.
• W640924987 cites W2159482845 @default.
• W640924987 cites W2161529281 @default.
• W640924987 cites W2163186054 @default.
• W640924987 cites W2166134689 @default.
• W640924987 cites W2167667334 @default.

• next