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- W64093875 abstract "Novel method to measure cardiac output (CO) in rats using an extracorporeal AV loop with ultrasound dilution (COD) technique is proposed and the results are validated with the established Transonic transit time (COTT) technology. Male Sprague-Dawley rats (n=6; 200–500gms) were instrumented with a 2.5SL transit time ascending aorta flow probe (Transonic Systems Inc.) for direct COTT. Following recovery, subjects were anesthetized with isoflurane and an extracorporeal loop was placed between the artery and jugular vein. Peristaltic pump (Instech Laboratories, Inc) was used to circulate blood (5–8ml/m) through the AV loop, during the procedure. COD was determined by injecting 30–50μl of isotonic saline into the venous side of the loop. An algorithm to automatically calculate COD (Transonic Systems, Inc.) was used to obtain COD in less than a minute after performing the injection. CO of the animal was varied by infusing drugs (dobutamine) & altering isoflurane level and the dynamic range was measured by both methods. COD and simultaneous COTT measurements were determined at least twice over the range of injected volumes. An acceptable correlation (r2 = 0.86) was observed between the two methods over a range of COTT from 50 to 130ml/m. Results obtained clearly indicate: COD provides reasonable estimate of CO in rats and can be used for measurements of drug-induced cardiovascular effects. (Support: NIH SBIR # R44 HL61994)" @default.
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- W64093875 date "2006-03-01" @default.
- W64093875 modified "2023-09-26" @default.
- W64093875 title "Measurement of Cardiac Output in Rats: Using Extracorporeal AV Loop with Ultrasound Dilution Technology – A Validation Study" @default.
- W64093875 doi "https://doi.org/10.1096/fasebj.20.5.a1411-c" @default.
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