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- W64132657 abstract "In 1973, when the presence of brain binding sites for compounds with opiate activity was demonstrated (Pert and Snyder, 1973; Simon et al., 1973; Terenius, 1973), the search for endogenous ligands for these putative opiate receptors was initiated. Two years later, Hughes et al. (1975) isolated two related pentapeptides from the brain of pigs that were called [Leu5]- and [Met5]enkephalin. Subsequently, β-endorphin (Li and Chung, 1976) and dynorphin B (Goldstein et al., 1979) were isolated. Interestingly, although opioid peptides are derived from different precursor molecules (for review see Höllt, 1986), they share at their N-terminal a [Met5]- or [Leu5]enkephalin sequence. The opioid peptides exert their biological effects via stimulation of specific receptors." @default.
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- W64132657 date "1991-01-01" @default.
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- W64132657 title "Endogenous Opioid Peptides, Glucocorticoids, and Shock: Specificity, Site, and Mechanism of Action" @default.
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- W64132657 doi "https://doi.org/10.1007/978-1-4615-9834-3_11" @default.
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