Matches in SemOpenAlex for { <https://semopenalex.org/work/W642405913> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W642405913 endingPage "967" @default.
- W642405913 startingPage "961" @default.
- W642405913 abstract "Lung cancer is the leading cause of cancer-mediated death. Although various therapeutic approaches are used for lung cancer treatment, these mainly target the tumor suppressor p53 transcription factor, which is involved in apoptosis and cell cycle arrest. However, p53-targeted therapies have limited application in lung cancer, since p53 is found to be mutated in more than half of lung cancers. In this study, we propose tumor suppressor FOXA2 as an alternative target protein for therapies against lung cancer and reveal a possible FOXA2-centered transcriptional regulation network by identifying new target genes and binding partners of FOXA2 by using various screening techniques. The genes encoding Glu/Asp-rich carboxy-terminal domain 2 (CITED2), nuclear receptor subfamily 0, group B, member 2 (NR0B2), cell adhesion molecule 1 (CADM1) and BCL2-associated X protein (BAX) were identified as putative target genes of FOXA2. Additionally, the proteins including highly similar to heat shock protein HSP 90-beta (HSP90A), heat shock 70 kDa protein 1A variant (HSPA1A), histone deacetylase 1 (HDAC1) and HDAC3 were identified as novel interacting partners of FOXA2. Moreover, we showed that FOXA2-dependent promoter activation of BAX and p21 genes is significantly reduced via physical interactions between the identified binding partners and FOXA2. These results provide opportunities to understand the FOXA2-centered transcriptional regulation network and novel therapeutic targets to modulate this network in p53-deficient lung cancer." @default.
- W642405913 created "2016-06-24" @default.
- W642405913 creator A5032150049 @default.
- W642405913 creator A5057442760 @default.
- W642405913 creator A5064253028 @default.
- W642405913 creator A5075326552 @default.
- W642405913 creator A5091718941 @default.
- W642405913 date "2015-08-01" @default.
- W642405913 modified "2023-10-14" @default.
- W642405913 title "Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer" @default.
- W642405913 cites W1972829847 @default.
- W642405913 cites W1977918192 @default.
- W642405913 cites W1978664503 @default.
- W642405913 cites W1983371747 @default.
- W642405913 cites W1994621739 @default.
- W642405913 cites W2003712822 @default.
- W642405913 cites W2013256245 @default.
- W642405913 cites W2020453630 @default.
- W642405913 cites W2022543078 @default.
- W642405913 cites W2026451392 @default.
- W642405913 cites W2051217690 @default.
- W642405913 cites W2054549064 @default.
- W642405913 cites W2058682074 @default.
- W642405913 cites W2063669247 @default.
- W642405913 cites W2068509272 @default.
- W642405913 cites W2082739624 @default.
- W642405913 cites W2091772830 @default.
- W642405913 cites W2100095241 @default.
- W642405913 cites W2115999568 @default.
- W642405913 cites W2155631307 @default.
- W642405913 cites W2159069437 @default.
- W642405913 cites W2167892935 @default.
- W642405913 cites W2168258970 @default.
- W642405913 cites W2169646249 @default.
- W642405913 cites W2340473180 @default.
- W642405913 doi "https://doi.org/10.1016/j.bbrc.2015.06.042" @default.
- W642405913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26093302" @default.
- W642405913 hasPublicationYear "2015" @default.
- W642405913 type Work @default.
- W642405913 sameAs 642405913 @default.
- W642405913 citedByCount "20" @default.
- W642405913 countsByYear W6424059132015 @default.
- W642405913 countsByYear W6424059132016 @default.
- W642405913 countsByYear W6424059132017 @default.
- W642405913 countsByYear W6424059132018 @default.
- W642405913 countsByYear W6424059132019 @default.
- W642405913 countsByYear W6424059132020 @default.
- W642405913 countsByYear W6424059132021 @default.
- W642405913 countsByYear W6424059132022 @default.
- W642405913 countsByYear W6424059132023 @default.
- W642405913 crossrefType "journal-article" @default.
- W642405913 hasAuthorship W642405913A5032150049 @default.
- W642405913 hasAuthorship W642405913A5057442760 @default.
- W642405913 hasAuthorship W642405913A5064253028 @default.
- W642405913 hasAuthorship W642405913A5075326552 @default.
- W642405913 hasAuthorship W642405913A5091718941 @default.
- W642405913 hasConcept C104317684 @default.
- W642405913 hasConcept C126322002 @default.
- W642405913 hasConcept C148397407 @default.
- W642405913 hasConcept C153911025 @default.
- W642405913 hasConcept C2776256026 @default.
- W642405913 hasConcept C502942594 @default.
- W642405913 hasConcept C54355233 @default.
- W642405913 hasConcept C71924100 @default.
- W642405913 hasConcept C86339819 @default.
- W642405913 hasConcept C86803240 @default.
- W642405913 hasConceptScore W642405913C104317684 @default.
- W642405913 hasConceptScore W642405913C126322002 @default.
- W642405913 hasConceptScore W642405913C148397407 @default.
- W642405913 hasConceptScore W642405913C153911025 @default.
- W642405913 hasConceptScore W642405913C2776256026 @default.
- W642405913 hasConceptScore W642405913C502942594 @default.
- W642405913 hasConceptScore W642405913C54355233 @default.
- W642405913 hasConceptScore W642405913C71924100 @default.
- W642405913 hasConceptScore W642405913C86339819 @default.
- W642405913 hasConceptScore W642405913C86803240 @default.
- W642405913 hasFunder F4320322120 @default.
- W642405913 hasIssue "4" @default.
- W642405913 hasLocation W6424059131 @default.
- W642405913 hasLocation W6424059132 @default.
- W642405913 hasOpenAccess W642405913 @default.
- W642405913 hasPrimaryLocation W6424059131 @default.
- W642405913 hasRelatedWork W2009966535 @default.
- W642405913 hasRelatedWork W2019988726 @default.
- W642405913 hasRelatedWork W2075811361 @default.
- W642405913 hasRelatedWork W2088063203 @default.
- W642405913 hasRelatedWork W2097265502 @default.
- W642405913 hasRelatedWork W2116673593 @default.
- W642405913 hasRelatedWork W2171277769 @default.
- W642405913 hasRelatedWork W2423871774 @default.
- W642405913 hasRelatedWork W2810423188 @default.
- W642405913 hasRelatedWork W3033910563 @default.
- W642405913 hasVolume "463" @default.
- W642405913 isParatext "false" @default.
- W642405913 isRetracted "false" @default.
- W642405913 magId "642405913" @default.
- W642405913 workType "article" @default.