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- W642529161 abstract "Pharmacokinetics and distribution of ciprofloxacin in various biological fluids were undertaken post i. v. dose (4 mg. kg-1) in goats. Peak concentrations of 2.53 ± 0.07, 12.23 ± 0.82 and 198.50 ± 25.89 µg.ml·' were attained at 0.083, I and 1 hr in plasma, milk and urine respectively. The therapeutic concentration (≥0.12 I1g.ml·') were maintained up to 10, 12 and 36 hr, respectively, in plasma, milk and urine. Distribution half life (t 1/2 α) and elimination half life (t, 1/2 β) of 0.32 ± 0.05 and 4.71 ± 0.67 hr were noted in the present study. Vd of 4.22 ± 0.51 L.kg-1 obtained for ciprofloxacin in goat denotes its wide distribution in the body. The present investigation suggests a loading dose (D*) of 4.4 mg.kg-1 followed by a maintenance dose (Do) of 3.8 mg.kg-1 at the dosage interval (γ) of 12 hr for maintaining therapeutic concentration (MIC) of 0.12 µg.ml·-1." @default.
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- W642529161 date "2001-01-01" @default.
- W642529161 modified "2023-09-24" @default.
- W642529161 title "Disposition kinetics and distribution of ciprofloxacin in biological fluids of goats after intravenous administration" @default.
- W642529161 hasPublicationYear "2001" @default.
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