Matches in SemOpenAlex for { <https://semopenalex.org/work/W64264908> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W64264908 endingPage "115.21" @default.
- W64264908 startingPage "115.21" @default.
- W64264908 abstract "Abstract HSV1 induced encephalitis in susceptible mice such as 129 and BALB/c mice is characterized by CNS inflammation associated with pathogenic Ly6Chigh macrophages and neutrophils. Mortality in this model correlates with degranulation by these cells rather than virus mediated cytopathology. IVIG, composed of pooled human IgG protects these mice by induction of regulatory CD4 T cells including IL-10 secreting Tregs and Tr1 cells secreting IL-10 and IFNγ. Surprisingly, IFNγ has an anti-inflammatory role in this model as infection of IFNγKO mice results in severe early morbidity and mortality associated with unabated CNS inflammation by neutrophils and Ly6Chigh monocytes suggesting that IFNγ is critical in the control of expansion of these cells. Interestingly, IVIG cannot protect IFNγKO mice despite control of infectious virus but not CNS inflammation typified by the inflammatory Ly6Chigh macrophages, indicating that IFNγ is crucial to IVIG’s anti-inflammatory activities. Adoptive transfer of T cells subsets from either WT or IFNγKO mice into Rag recipients reinforced the importance of IFNγ on CNS inflammation. Furthermore, IFNγ appears to have a role in the IVIG induced expansion of Tregs while in the absence of IFNγ, there was an increase in γδ T cells secreting IL-17, which may contribute to the early unmitigated expansion of the neutrophils and monocytes. IFNγ related effects on CEACAM1a and iNOS on monocytes, on Tregs, and the cell subset that secretes IFNγ will be discussed." @default.
- W64264908 created "2016-06-24" @default.
- W64264908 creator A5014254166 @default.
- W64264908 creator A5027191469 @default.
- W64264908 creator A5066057880 @default.
- W64264908 date "2011-04-01" @default.
- W64264908 modified "2023-09-27" @default.
- W64264908 title "Anti inflammatory role of IFN gamma in a viral model of encephalitis (115.21)" @default.
- W64264908 doi "https://doi.org/10.4049/jimmunol.186.supp.115.21" @default.
- W64264908 hasPublicationYear "2011" @default.
- W64264908 type Work @default.
- W64264908 sameAs 64264908 @default.
- W64264908 citedByCount "1" @default.
- W64264908 countsByYear W642649082013 @default.
- W64264908 crossrefType "journal-article" @default.
- W64264908 hasAuthorship W64264908A5014254166 @default.
- W64264908 hasAuthorship W64264908A5027191469 @default.
- W64264908 hasAuthorship W64264908A5066057880 @default.
- W64264908 hasConcept C159047783 @default.
- W64264908 hasConcept C170493617 @default.
- W64264908 hasConcept C203014093 @default.
- W64264908 hasConcept C2522874641 @default.
- W64264908 hasConcept C2776090121 @default.
- W64264908 hasConcept C2776914184 @default.
- W64264908 hasConcept C2779734145 @default.
- W64264908 hasConcept C49802076 @default.
- W64264908 hasConcept C55493867 @default.
- W64264908 hasConcept C71924100 @default.
- W64264908 hasConcept C83455156 @default.
- W64264908 hasConcept C86803240 @default.
- W64264908 hasConcept C8891405 @default.
- W64264908 hasConcept C90375314 @default.
- W64264908 hasConceptScore W64264908C159047783 @default.
- W64264908 hasConceptScore W64264908C170493617 @default.
- W64264908 hasConceptScore W64264908C203014093 @default.
- W64264908 hasConceptScore W64264908C2522874641 @default.
- W64264908 hasConceptScore W64264908C2776090121 @default.
- W64264908 hasConceptScore W64264908C2776914184 @default.
- W64264908 hasConceptScore W64264908C2779734145 @default.
- W64264908 hasConceptScore W64264908C49802076 @default.
- W64264908 hasConceptScore W64264908C55493867 @default.
- W64264908 hasConceptScore W64264908C71924100 @default.
- W64264908 hasConceptScore W64264908C83455156 @default.
- W64264908 hasConceptScore W64264908C86803240 @default.
- W64264908 hasConceptScore W64264908C8891405 @default.
- W64264908 hasConceptScore W64264908C90375314 @default.
- W64264908 hasIssue "1_Supplement" @default.
- W64264908 hasLocation W642649081 @default.
- W64264908 hasOpenAccess W64264908 @default.
- W64264908 hasPrimaryLocation W642649081 @default.
- W64264908 hasRelatedWork W2018427314 @default.
- W64264908 hasRelatedWork W2018681560 @default.
- W64264908 hasRelatedWork W2021084373 @default.
- W64264908 hasRelatedWork W2021255975 @default.
- W64264908 hasRelatedWork W2096211910 @default.
- W64264908 hasRelatedWork W2128694535 @default.
- W64264908 hasRelatedWork W2144567501 @default.
- W64264908 hasRelatedWork W2158705418 @default.
- W64264908 hasRelatedWork W2350707511 @default.
- W64264908 hasRelatedWork W2472613104 @default.
- W64264908 hasVolume "186" @default.
- W64264908 isParatext "false" @default.
- W64264908 isRetracted "false" @default.
- W64264908 magId "64264908" @default.
- W64264908 workType "article" @default.