Matches in SemOpenAlex for { <https://semopenalex.org/work/W64267049> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W64267049 endingPage "12" @default.
- W64267049 startingPage "107" @default.
- W64267049 abstract "Although most wounds heal rapidly, impaired or delayed tissue repair represents a major clinical challenge. Current therapy is directed at providing a wound with the most favorable environment in which to heal, rather than aiming to increase the rate of healing pharmacologically. Recent studies have suggested that a number of drugs may act specifically to increase healing rates. In vivo studies have demonstrated that recombinant human granulocyte-macrophage colony-stimulating factor facilitates wound contraction, causes local recruitment of inflammatory cells, and induces keratinocyte proliferation. It also activates mononuclear phagocytes, promotes migration of epithelial cells, and further regulates cytokine production. In 2 recent placebo-controlled studies involving venous leg ulceration, subcutaneous perilesional injections of recombinant human granulocyte-macrophage colony-stimulating factor were found to be significantly better than placebo in the time to complete wound healing. In other studies, recombinant human granulocyte-macrophage colony-stimulating factor was administered topically to wounds. Several case reports have also demonstrated the use of recombinant human granulocyte-macrophage colony-stimulating factor for postsurgical wounds, chronic leg ulcers of sickle cell anemia patients, and refractory pyoderma gangrenosum. Despite proper attention to wound care, some wounds fail to heal in an appropriate fashion and may become chronic. Studies of wound physiology as well as experimental and clinical evidence suggest that recombinant human granulocyte-macrophage colony-stimulating factor may promote healing of these lesions." @default.
- W64267049 created "2016-06-24" @default.
- W64267049 creator A5015943889 @default.
- W64267049 creator A5072641302 @default.
- W64267049 date "2000-11-15" @default.
- W64267049 modified "2023-09-27" @default.
- W64267049 title "Recombinant human GM-CSF in the treatment of poorly healing wounds." @default.
- W64267049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11075003" @default.
- W64267049 hasPublicationYear "2000" @default.
- W64267049 type Work @default.
- W64267049 sameAs 64267049 @default.
- W64267049 citedByCount "20" @default.
- W64267049 countsByYear W642670492013 @default.
- W64267049 countsByYear W642670492014 @default.
- W64267049 countsByYear W642670492015 @default.
- W64267049 countsByYear W642670492019 @default.
- W64267049 countsByYear W642670492023 @default.
- W64267049 crossrefType "journal-article" @default.
- W64267049 hasAuthorship W64267049A5015943889 @default.
- W64267049 hasAuthorship W64267049A5072641302 @default.
- W64267049 hasConcept C109159458 @default.
- W64267049 hasConcept C142724271 @default.
- W64267049 hasConcept C202751555 @default.
- W64267049 hasConcept C203014093 @default.
- W64267049 hasConcept C2777478134 @default.
- W64267049 hasConcept C2777983669 @default.
- W64267049 hasConcept C2778690821 @default.
- W64267049 hasConcept C2779134260 @default.
- W64267049 hasConcept C2779244956 @default.
- W64267049 hasConcept C2780269544 @default.
- W64267049 hasConcept C2780520777 @default.
- W64267049 hasConcept C28328180 @default.
- W64267049 hasConcept C54355233 @default.
- W64267049 hasConcept C55493867 @default.
- W64267049 hasConcept C71924100 @default.
- W64267049 hasConcept C86803240 @default.
- W64267049 hasConcept C880424 @default.
- W64267049 hasConcept C98274493 @default.
- W64267049 hasConceptScore W64267049C109159458 @default.
- W64267049 hasConceptScore W64267049C142724271 @default.
- W64267049 hasConceptScore W64267049C202751555 @default.
- W64267049 hasConceptScore W64267049C203014093 @default.
- W64267049 hasConceptScore W64267049C2777478134 @default.
- W64267049 hasConceptScore W64267049C2777983669 @default.
- W64267049 hasConceptScore W64267049C2778690821 @default.
- W64267049 hasConceptScore W64267049C2779134260 @default.
- W64267049 hasConceptScore W64267049C2779244956 @default.
- W64267049 hasConceptScore W64267049C2780269544 @default.
- W64267049 hasConceptScore W64267049C2780520777 @default.
- W64267049 hasConceptScore W64267049C28328180 @default.
- W64267049 hasConceptScore W64267049C54355233 @default.
- W64267049 hasConceptScore W64267049C55493867 @default.
- W64267049 hasConceptScore W64267049C71924100 @default.
- W64267049 hasConceptScore W64267049C86803240 @default.
- W64267049 hasConceptScore W64267049C880424 @default.
- W64267049 hasConceptScore W64267049C98274493 @default.
- W64267049 hasIssue "3 Pt 1" @default.
- W64267049 hasLocation W642670491 @default.
- W64267049 hasOpenAccess W64267049 @default.
- W64267049 hasPrimaryLocation W642670491 @default.
- W64267049 hasRelatedWork W1605376961 @default.
- W64267049 hasRelatedWork W1837517610 @default.
- W64267049 hasRelatedWork W2058042162 @default.
- W64267049 hasRelatedWork W2085596039 @default.
- W64267049 hasRelatedWork W2132181226 @default.
- W64267049 hasRelatedWork W2146899977 @default.
- W64267049 hasRelatedWork W2346596249 @default.
- W64267049 hasRelatedWork W2361699662 @default.
- W64267049 hasRelatedWork W2411326673 @default.
- W64267049 hasRelatedWork W3025900842 @default.
- W64267049 hasVolume "13" @default.
- W64267049 isParatext "false" @default.
- W64267049 isRetracted "false" @default.
- W64267049 magId "64267049" @default.
- W64267049 workType "article" @default.