FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W642932259> ?p ?o ?g. }

• W642932259 endingPage "827" @default.
• W642932259 startingPage "817" @default.
• W642932259 abstract "In this study, we have reported the molecular information of chemokine-19 (Chem19) from striped murrel Channa striatus (Cs). CsCC-Chem19 cDNA sequence was 555 base pair (bp) in length which is 68 bp 5′ untranslated region (UTR), 339 bp translated region and 149 bp 3′ UTR. The translated region is encoded for a polypeptide of 112 amino acids. CsCC-Chem19 peptide contains a signal sequence between 1 and 26 and an interleukin (IL) 8 like domain between 24 and 89. The multiple sequence alignment showed a ‘DCCL’ motif, an indispensable motif present in all CC chemokines which was conserved throughout the evolution. Phylogenetic tree showed that CsCC-Chem19 formed a cluster with chemokine 19 from fishes. Secondary structure of CsCC-Chem19 revealed that the peptide contains maximum amount of coils (61.6%) compared to α-helices (25.9%%) and β-sheet (12.5%). Further, 3D analysis indicated that the cysteine residues at 33, 34, 59 and 75 making the disulfide bridges as 33 = 59 and 34 = 75. Significantly (P < 0.05) highest CsCC-Chem19 mRNA expression was observed in blood and it was up-regulated upon fungus and bacterial infection. Utilizing the coding region of CsCC-Chem19, recombinant CsCC-Chem19 protein was produced. The recombinant CsCC-Chem19 protein induced the cellular proliferation and respiratory burst activity of C. striatus peripheral blood leukocytes (PBL) in a concentration dependent manner. Moreover, the chemotactic activity showed that the recombinant CsCC-Chem19 significantly (P < 0.05) enhanced the movement of PBL of C. striatus. Conclusively, CsCC-Chem19 is a 6C CC chemokine having an ability to perform both inflammatory and homeostatic functions. However, further research is necessary to understand the potential of 6C CC chemokine 19 of C. striatus, particularly their regulatory ability on different cellular components in the defense system." @default.
• W642932259 created "2016-06-24" @default.
• W642932259 creator A5019642989 @default.
• W642932259 creator A5044024787 @default.
• W642932259 creator A5050206301 @default.
• W642932259 creator A5056131342 @default.
• W642932259 creator A5070138991 @default.
• W642932259 date "2015-08-01" @default.
• W642932259 modified "2023-10-16" @default.
• W642932259 title "Molecular and functional roles of 6C CC chemokine 19 in defense system of striped murrel Channa striatus" @default.
• W642932259 cites W1492133200 @default.
• W642932259 cites W1507898351 @default.
• W642932259 cites W1542929556 @default.
• W642932259 cites W1598202087 @default.
• W642932259 cites W1964232079 @default.
• W642932259 cites W1967876529 @default.
• W642932259 cites W1975428379 @default.
• W642932259 cites W1978246671 @default.
• W642932259 cites W1979483306 @default.
• W642932259 cites W1980544070 @default.
• W642932259 cites W1985448984 @default.
• W642932259 cites W1988337200 @default.
• W642932259 cites W1989528460 @default.
• W642932259 cites W1989785466 @default.
• W642932259 cites W1990365217 @default.
• W642932259 cites W1992099349 @default.
• W642932259 cites W1993006141 @default.
• W642932259 cites W1994657043 @default.
• W642932259 cites W1996437925 @default.
• W642932259 cites W2005265253 @default.
• W642932259 cites W2005502336 @default.
• W642932259 cites W2005659566 @default.
• W642932259 cites W2007741751 @default.
• W642932259 cites W2008169330 @default.
• W642932259 cites W2015293880 @default.
• W642932259 cites W2019460610 @default.
• W642932259 cites W2020617877 @default.
• W642932259 cites W2020686859 @default.
• W642932259 cites W2023096047 @default.
• W642932259 cites W2025159406 @default.
• W642932259 cites W2026894281 @default.
• W642932259 cites W2033074169 @default.
• W642932259 cites W2044961357 @default.
• W642932259 cites W2045051090 @default.
• W642932259 cites W2046590214 @default.
• W642932259 cites W2047426822 @default.
• W642932259 cites W2053902929 @default.
• W642932259 cites W2054989216 @default.
• W642932259 cites W2056260661 @default.
• W642932259 cites W2060888441 @default.
• W642932259 cites W2062521099 @default.
• W642932259 cites W2062814034 @default.
• W642932259 cites W2063160102 @default.
• W642932259 cites W2067535806 @default.
• W642932259 cites W2080111135 @default.
• W642932259 cites W2083421880 @default.
• W642932259 cites W2083698231 @default.
• W642932259 cites W2084168484 @default.
• W642932259 cites W2091599169 @default.
• W642932259 cites W2094637827 @default.
• W642932259 cites W2100852741 @default.
• W642932259 cites W2101372562 @default.
• W642932259 cites W2102540234 @default.
• W642932259 cites W2106485291 @default.
• W642932259 cites W2107277218 @default.
• W642932259 cites W2125079066 @default.
• W642932259 cites W2128593833 @default.
• W642932259 cites W2135603552 @default.
• W642932259 cites W2142143111 @default.
• W642932259 cites W2152207030 @default.
• W642932259 cites W2157464163 @default.
• W642932259 cites W2168193216 @default.
• W642932259 cites W252614480 @default.
• W642932259 cites W4234072569 @default.
• W642932259 cites W4293247451 @default.
• W642932259 doi "https://doi.org/10.1016/j.fsi.2015.06.001" @default.
• W642932259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26057460" @default.
• W642932259 hasPublicationYear "2015" @default.
• W642932259 type Work @default.
• W642932259 sameAs 642932259 @default.
• W642932259 citedByCount "23" @default.
• W642932259 countsByYear W6429322592015 @default.
• W642932259 countsByYear W6429322592016 @default.
• W642932259 countsByYear W6429322592017 @default.
• W642932259 countsByYear W6429322592018 @default.
• W642932259 countsByYear W6429322592019 @default.
• W642932259 countsByYear W6429322592020 @default.
• W642932259 countsByYear W6429322592021 @default.
• W642932259 countsByYear W6429322592022 @default.
• W642932259 countsByYear W6429322592023 @default.
• W642932259 crossrefType "journal-article" @default.
• W642932259 hasAuthorship W642932259A5019642989 @default.
• W642932259 hasAuthorship W642932259A5044024787 @default.
• W642932259 hasAuthorship W642932259A5050206301 @default.
• W642932259 hasAuthorship W642932259A5056131342 @default.
• W642932259 hasAuthorship W642932259A5070138991 @default.
• W642932259 hasConcept C104317684 @default.
• W642932259 hasConcept C105580179 @default.

• next