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- W6430889 abstract "The goal of this study is to investigate the regulation of C/EBPδ transcriptional activity by PIASy (protein inhibitor of activated STAT4). C/EBPδ functions in growth control of mammary epithelial cells. Although C/EBPδ lysine 120 (K120) is a target for sumoylation, SUMO1 over-expression did not affect C/EBPδ transcriptional activity. Co-expression of PIASy, a SUMO ligase, however, repressed C/EBPδ transcriptional activity without enhancing C/EBPδ sumoylation. PIASy also inhibited transcriptional activity of the sumoylation defective C/EBPδ K120R mutant. To investigate the mechanism underlying PIASy inhibition of C/EBPδ we assessed the interaction between C/EBPδ and PIASy and found that the PIASy SAP nuclear matrix binding domain physically interacts with the C/EBPδ N-terminal transactivation domain. PIASy mutant construct lacking the SAP domain did not repress C/EBPδ transcriptional activity. Subcellular localization experiments demonstrated that C/EBPδ is concentrated in transcriptionally active nuclear foci but PIASy expression disrupted C/EBPδ nuclear localization. SAP mutant PIASy had no effect on C/EBPδ nuclear localization. These results demonstrate that PIASy repression of C/EBPδ transcriptional activity is independent of SUMO ligase activity. PIASy represses C/EBPδ transcriptional activity by sequestering C/EBPδ from transcriptionally active nuclear foci. NIH CA57607" @default.
- W6430889 created "2016-06-24" @default.
- W6430889 creator A5084880003 @default.
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- W6430889 date "2007-01-01" @default.
- W6430889 modified "2023-09-26" @default.
- W6430889 title "Regulation of CCAAT/enhancer binding protein delta (C/EBP delta) transcriptional activity by PIASy" @default.
- W6430889 doi "https://doi.org/10.1096/fasebj.21.6.a1030" @default.
- W6430889 hasPublicationYear "2007" @default.
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