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- W64309946 abstract "Acute stroke, ischemic, hypertension, antihypertensive drugs. The results of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) study were presented last month at the 2013 American Heart Association Scientific Meeting and simultaneously published in the Journal of the American Medical Association [1]. The CATIS study was a multicen-ter, controlled, randomized study that aimed to assess the effects of blood pressure reduction during the acute phase of ischemic stroke on death and major disability at 14 days and 3 months after the episode. The stroke was confirmed by brain CT or MRI and systolic blood pressure levels between 140-220 mmHg were required to enter the study. About half of screened patients with an acute ischemic stroke and hyper-tension fulfilled all inclusion/exclusion criteria and entered the study (2,038 out of 4,071). Study participants were randomly assigned to receive or not antihypertensive therapy within 48 hours of stroke onset. In particular, a graded blood pressure reduction was aimed in the active group targeting a 10-25% reduction during the first study day and blood pressure control during the first week post-randomization. In contrast, no antihypertensive therapy was given in the control group and previous anti-hypertensive medication was discontinued during the acute phase of stroke. After the first week, all patients received antihypertensive therapy to achieve blood pressure control (<140/90 mmHg). Blood pressure was significantly reduced in both groups during the first 24h post-randomization; however, the reduc-tion was significantly greater in the active compared to the control group (21.8 versus 12.7 mmHg; between group dif-ference: 9.1 mmHg; 95% CI: 8.1-10.2; p<0.001). Similarly, blood pressure levels were significantly lower in the active group at 7 days post-randomization (between group differ-ence 9.3 mmHg; 95% CI: 8.4-10.1; p<0.001). The primary outcome (death or major disability at 14 days or hospital discharge) was identical in the two groups (odds ratio: 1.00; 95% CI: 0.88-1.14; p=0.98). The secondary outcome (death larger study, the Scandinavian Candesartan Acute Stroke" @default.
- W64309946 created "2016-06-24" @default.
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- W64309946 date "2014-01-01" @default.
- W64309946 modified "2023-09-26" @default.
- W64309946 title "Antihypertensive Therapy in Acute Ischemic Stroke: Lost in the Mist" @default.
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