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- W6431407 abstract "Summary The nonenzymatic glycosylation of nucleic acids In vitro and in vivo has been shown to have adverse effects on both their functional activity and biological integrity. In vitro and in vivo prokaryotic and eukaryotic model systems have demonstrated the effect of glucose-modified DNA on the induction of a number of significant genetic alterations. We have expanded these investigations to a mammalian system; transgenic mice containing the bacterial mutagenesis marker lacI. Using lacI. transgenic mice, we have performed a comparative analysis of age-related DNA mutations in splenic tissue and studied the influence of a hyperglycemic maternal environment on the lacI mutation frequency of developing transgenic embryos." @default.
- W6431407 created "2016-06-24" @default.
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- W6431407 date "2005-01-01" @default.
- W6431407 modified "2023-10-16" @default.
- W6431407 title "Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo" @default.
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- W6431407 doi "https://doi.org/10.1533/9781845698393.4.249" @default.
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