Matches in SemOpenAlex for { <https://semopenalex.org/work/W6436747> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W6436747 endingPage "70" @default.
- W6436747 startingPage "S64" @default.
- W6436747 abstract "Human telomerase is highly active in more than 85% of primary cancers, regardless of their tissue origins, but not in most differentiated somatic tissues. Because of this, telomerase recently has become a popular target of anticancer therapy and has been used as a marker of cancer. Similarly, telomerase promoters, especially telomerase reverse transcriptase (TERT) promoter, have been zealously tested for targeted cancer gene therapy. In vitro and in vivo studies have demonstrated that the human TERT (hTERT) promoter is highly active in human and murine cancer cells but not in normal differentiated human cells, normal human CD34(+) progenitor cells, normal mouse fibroblasts, or normal mouse livers. Moreover, transcription factors can dramatically augment transgene expression from the hTERT promoter without the promoter losing its specificity. Thus far, telomerase promoters have been tested for targeted cancer gene therapy with proapoptotic, cytotoxic, and prodrug-activating genes and with replication-competent viral vectors. Here, we review recent achievements in telomerase promoter-based targeted cancer gene therapy." @default.
- W6436747 created "2016-06-24" @default.
- W6436747 creator A5027007747 @default.
- W6436747 creator A5034128046 @default.
- W6436747 date "2003-09-26" @default.
- W6436747 modified "2023-10-16" @default.
- W6436747 title "Telomerase promoter-driven cancer gene therapy." @default.
- W6436747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14508082" @default.
- W6436747 hasPublicationYear "2003" @default.
- W6436747 type Work @default.
- W6436747 sameAs 6436747 @default.
- W6436747 citedByCount "18" @default.
- W6436747 countsByYear W64367472012 @default.
- W6436747 countsByYear W64367472016 @default.
- W6436747 countsByYear W64367472017 @default.
- W6436747 countsByYear W64367472019 @default.
- W6436747 countsByYear W64367472021 @default.
- W6436747 crossrefType "journal-article" @default.
- W6436747 hasAuthorship W6436747A5027007747 @default.
- W6436747 hasAuthorship W6436747A5034128046 @default.
- W6436747 hasConcept C101762097 @default.
- W6436747 hasConcept C102230213 @default.
- W6436747 hasConcept C104317684 @default.
- W6436747 hasConcept C111599444 @default.
- W6436747 hasConcept C121608353 @default.
- W6436747 hasConcept C125593758 @default.
- W6436747 hasConcept C150194340 @default.
- W6436747 hasConcept C153911025 @default.
- W6436747 hasConcept C502942594 @default.
- W6436747 hasConcept C54355233 @default.
- W6436747 hasConcept C86803240 @default.
- W6436747 hasConcept C94581717 @default.
- W6436747 hasConcept C96232424 @default.
- W6436747 hasConceptScore W6436747C101762097 @default.
- W6436747 hasConceptScore W6436747C102230213 @default.
- W6436747 hasConceptScore W6436747C104317684 @default.
- W6436747 hasConceptScore W6436747C111599444 @default.
- W6436747 hasConceptScore W6436747C121608353 @default.
- W6436747 hasConceptScore W6436747C125593758 @default.
- W6436747 hasConceptScore W6436747C150194340 @default.
- W6436747 hasConceptScore W6436747C153911025 @default.
- W6436747 hasConceptScore W6436747C502942594 @default.
- W6436747 hasConceptScore W6436747C54355233 @default.
- W6436747 hasConceptScore W6436747C86803240 @default.
- W6436747 hasConceptScore W6436747C94581717 @default.
- W6436747 hasConceptScore W6436747C96232424 @default.
- W6436747 hasIssue "4 Suppl 1" @default.
- W6436747 hasLocation W64367471 @default.
- W6436747 hasOpenAccess W6436747 @default.
- W6436747 hasPrimaryLocation W64367471 @default.
- W6436747 hasRelatedWork W1863328279 @default.
- W6436747 hasRelatedWork W1966510795 @default.
- W6436747 hasRelatedWork W2009724739 @default.
- W6436747 hasRelatedWork W2059791776 @default.
- W6436747 hasRelatedWork W2117232345 @default.
- W6436747 hasRelatedWork W2159233376 @default.
- W6436747 hasRelatedWork W2321037413 @default.
- W6436747 hasRelatedWork W2398626654 @default.
- W6436747 hasRelatedWork W2597191915 @default.
- W6436747 hasRelatedWork W2980283681 @default.
- W6436747 hasVolume "2" @default.
- W6436747 isParatext "false" @default.
- W6436747 isRetracted "false" @default.
- W6436747 magId "6436747" @default.
- W6436747 workType "article" @default.