Matches in SemOpenAlex for { <https://semopenalex.org/work/W64434556> ?p ?o ?g. }
- W64434556 endingPage "480" @default.
- W64434556 startingPage "467" @default.
- W64434556 abstract "Abstract Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections. To evaluate features unique to immune reconstitution after unrelated BMT, the lymphoid phenotype, in vitro function, and life-threatening opportunistic infections after unrelated and related T-cell–depleted (TCD) BMT were analyzed longitudinally and compared. The effects of posttransplant donor leukocyte infusions to treat or prevent cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections on immune reconstitution were also analyzed. This study demonstrates that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3+, CD4+, and CD8+ T-cell populations when compared with pediatric recipients of unrelated BMT and adults after related BMT (P < .01), that these adults have a significantly increased risk of life-threatening opportunistic infections, and that the rate of recovery of CD4 T cells correlates with the risk of developing these infections. Recovery of normal numbers of CD3+, CD8+, and CD4+ T-cell populations is similar in children after related or unrelated BMT. This study also demonstrates that adoptive immunotherapy with small numbers of unirradiated donor leukocytes can be associated with rapid restoration of CD3+, CD4+, and CD8+T-cell numbers, antigen-specific T-cell responses, and resolution of CMV- and EBV-associated disease after unrelated TCD BMT." @default.
- W64434556 created "2016-06-24" @default.
- W64434556 creator A5004619863 @default.
- W64434556 creator A5007786900 @default.
- W64434556 creator A5015266579 @default.
- W64434556 creator A5030178053 @default.
- W64434556 creator A5031035765 @default.
- W64434556 creator A5031349996 @default.
- W64434556 creator A5032817291 @default.
- W64434556 creator A5036520753 @default.
- W64434556 creator A5041242319 @default.
- W64434556 creator A5043966208 @default.
- W64434556 creator A5058476408 @default.
- W64434556 creator A5058746837 @default.
- W64434556 creator A5059231900 @default.
- W64434556 creator A5065221178 @default.
- W64434556 creator A5067712388 @default.
- W64434556 creator A5079103223 @default.
- W64434556 creator A5090388594 @default.
- W64434556 date "1999-01-15" @default.
- W64434556 modified "2023-10-14" @default.
- W64434556 title "Comparison of Immune Reconstitution After Unrelated and Related T-Cell–Depleted Bone Marrow Transplantation: Effect of Patient Age and Donor Leukocyte Infusions" @default.
- W64434556 cites W1504399806 @default.
- W64434556 cites W1519981272 @default.
- W64434556 cites W1533537097 @default.
- W64434556 cites W1539005347 @default.
- W64434556 cites W1545991364 @default.
- W64434556 cites W1571009995 @default.
- W64434556 cites W1965359675 @default.
- W64434556 cites W1967466109 @default.
- W64434556 cites W1977635228 @default.
- W64434556 cites W1981182568 @default.
- W64434556 cites W1985926641 @default.
- W64434556 cites W201756653 @default.
- W64434556 cites W2025383600 @default.
- W64434556 cites W2030024150 @default.
- W64434556 cites W2048791531 @default.
- W64434556 cites W205206349 @default.
- W64434556 cites W2054425626 @default.
- W64434556 cites W2062403893 @default.
- W64434556 cites W2108238886 @default.
- W64434556 cites W2112041130 @default.
- W64434556 cites W2132672859 @default.
- W64434556 cites W2141099302 @default.
- W64434556 cites W2143908115 @default.
- W64434556 cites W2164524008 @default.
- W64434556 cites W2170521198 @default.
- W64434556 cites W2171042621 @default.
- W64434556 cites W2204388837 @default.
- W64434556 cites W2317117822 @default.
- W64434556 cites W2336508405 @default.
- W64434556 cites W2344784341 @default.
- W64434556 cites W2403167642 @default.
- W64434556 cites W2407208193 @default.
- W64434556 cites W2408278513 @default.
- W64434556 cites W2418923041 @default.
- W64434556 cites W2418956611 @default.
- W64434556 cites W2485473323 @default.
- W64434556 cites W261012566 @default.
- W64434556 cites W315543599 @default.
- W64434556 doi "https://doi.org/10.1182/blood.v93.2.467" @default.
- W64434556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9885208" @default.
- W64434556 hasPublicationYear "1999" @default.
- W64434556 type Work @default.
- W64434556 sameAs 64434556 @default.
- W64434556 citedByCount "463" @default.
- W64434556 countsByYear W644345562012 @default.
- W64434556 countsByYear W644345562013 @default.
- W64434556 countsByYear W644345562014 @default.
- W64434556 countsByYear W644345562015 @default.
- W64434556 countsByYear W644345562016 @default.
- W64434556 countsByYear W644345562017 @default.
- W64434556 countsByYear W644345562018 @default.
- W64434556 countsByYear W644345562019 @default.
- W64434556 countsByYear W644345562020 @default.
- W64434556 countsByYear W644345562021 @default.
- W64434556 countsByYear W644345562022 @default.
- W64434556 countsByYear W644345562023 @default.
- W64434556 crossrefType "journal-article" @default.
- W64434556 hasAuthorship W64434556A5004619863 @default.
- W64434556 hasAuthorship W64434556A5007786900 @default.
- W64434556 hasAuthorship W64434556A5015266579 @default.
- W64434556 hasAuthorship W64434556A5030178053 @default.
- W64434556 hasAuthorship W64434556A5031035765 @default.
- W64434556 hasAuthorship W64434556A5031349996 @default.
- W64434556 hasAuthorship W64434556A5032817291 @default.
- W64434556 hasAuthorship W64434556A5036520753 @default.
- W64434556 hasAuthorship W64434556A5041242319 @default.
- W64434556 hasAuthorship W64434556A5043966208 @default.
- W64434556 hasAuthorship W64434556A5058476408 @default.
- W64434556 hasAuthorship W64434556A5058746837 @default.
- W64434556 hasAuthorship W64434556A5059231900 @default.
- W64434556 hasAuthorship W64434556A5065221178 @default.
- W64434556 hasAuthorship W64434556A5067712388 @default.
- W64434556 hasAuthorship W64434556A5079103223 @default.
- W64434556 hasAuthorship W64434556A5090388594 @default.
- W64434556 hasConcept C126322002 @default.
- W64434556 hasConcept C167672396 @default.