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- W644425297 abstract "1287 Learning Objectives To describe the pathogenesis and manifestations of splenic marginal zone lymphoma (SMZL) and findings on FDG PET scan. SMZL comprises less than 5% of all non-Hodgkin’s lymphoma (NHL) and about 1% of all B-cell lymphomas. It occurs at an average age of 65; uncommon before 50. Approximately 80% of patients have abnormal karyotype. SMZL is likely arising from a post germinal center, memory B cell of splenic type. The pathogenesis of disease is unclear. It is associated with viral infections, such as hepatitis C and Kaposi’s sarcoma-associated herpes virus. The typical manifestations are splenomegaly, lymphocytosis, and cytopenia (because of hypersplenism). Compared to other NHLs, lymph node and extralymphatic organs involvement are uncommon in SMZL. Peripheral blood, focal bone marrow and liver involvement are common. The diagnosis is made based on assessment of lymphocyte morphology, immunophenotype, cytogenetic analysis, bone marrow biopsy, and spleen histology (if available). Most of the cases are in stage IV at presentation. The malignant cells replace white pulp germinal centers of the spleen, merging with an outer marginal zone of larger cells with pale cytoplasm. The red pulp is infiltrated with both small and large cells, often with villous lymphocytes circulating in the peripheral blood. The course is usually very indolent, with a median overall survival of 10 years or more. No PET imaging of SMZL has been reported in literature." @default.
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- W644425297 date "2013-05-01" @default.
- W644425297 modified "2023-09-23" @default.
- W644425297 title "Clinical and FDG PET/CT scan presentation of splenic marginal zone lymphoma" @default.
- W644425297 hasPublicationYear "2013" @default.
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