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- W644600352 abstract "Inspired by naturally occurring pH-regulated receptors, here we propose a rational approach to introduce pH-induced allostery into a wide range of DNA-based receptors. To demonstrate this we re-engineered two model DNA-based probes, a molecular beacon and a cocaine-binding aptamer, by introducing in their sequence a pH-dependent domain. We demonstrate here that we can finely tune the affinity of these model receptors and control the load/release of their specific target molecule by a simple pH change." @default.
- W644600352 created "2016-06-24" @default.
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- W644600352 date "2015-06-10" @default.
- W644600352 modified "2023-10-12" @default.
- W644600352 title "General Strategy to Introduce pH-Induced Allostery in DNA-Based Receptors to Achieve Controlled Release of Ligands" @default.
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- W644600352 doi "https://doi.org/10.1021/acs.nanolett.5b00852" @default.
- W644600352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498449" @default.
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