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- W64487264 abstract "Results from quantitative PCR analysis of the frequency of deleted mitochondrial genomes in male Fischer 344 rats reveal an age-related rise in this molecular abnormality. We used this model to examine the ability of dietary restriction (DR) to prevent this potentially pathogenic change. DR prevented age-related increase in frequency of mitochondrial deletions in the liver. In contrast, however, DR had no effect on the age-related increase in deletion frequency in the brain. These data suggest that the effects of DR on age-related accumulation of mitochondrial DNA deletions may be tissue specific." @default.
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- W64487264 date "1998-01-01" @default.
- W64487264 modified "2023-10-16" @default.
- W64487264 title "Age-Related Mitochondrial DNA Deletions" @default.
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- W64487264 doi "https://doi.org/10.1016/s0891-5849(97)00204-9" @default.
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