Matches in SemOpenAlex for { <https://semopenalex.org/work/W645171471> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W645171471 endingPage "599" @default.
- W645171471 startingPage "545" @default.
- W645171471 abstract "Viruses are obligate intracellular parasites or symbionts and depend on cells for their replication. Nowhere is this dependency seen more clearly than in the translation system, as viruses—unlike cells and their endosymbiotic organelles, chloroplasts and mitochondria—lack a translational apparatus. Consequently, viruses must use the cellular apparatus for the synthesis of one of their principal components. Because they can be manipulated with relative ease, the study of viruses has been a pre-eminent source of information on the mechanism and regulation of the protein synthetic machinery (Table 1). Viruses do more than simply co-opt the cellular machinery to produce viral proteins, however. Under extreme selection pressure, many viruses have evolved ways to gain a translational advantage for their mRNAs and to contend with potent host defense systems that affect protein synthesis. Here we consider the interactions between viruses and the translation system of the cell under three headings: Translational mechanisms. Viruses exploit a range of unorthodox mechanisms, most of which were discovered in viral systems. Many of them have proven to be used in the uninfected cell, albeit seemingly less frequently or in special circumstances such as during apoptosis or in response to environmental stress. Modifications of the translation system. Many viruses impose sweeping changes upon the cellular translation machinery and the signaling network that regulates it, modifying these systems to favor the synthesis of viral proteins at the cells’ expense. Host defenses and viral countermeasures. Host defenses impinge on translation at many levels, from direct effects..." @default.
- W645171471 created "2016-06-24" @default.
- W645171471 creator A5018004018 @default.
- W645171471 creator A5024099273 @default.
- W645171471 creator A5055851463 @default.
- W645171471 date "2007-01-01" @default.
- W645171471 modified "2023-09-26" @default.
- W645171471 title "20 Protein Synthesis and Translational Control during Viral Infection" @default.
- W645171471 doi "https://doi.org/10.1101/087969767.48.545" @default.
- W645171471 hasPublicationYear "2007" @default.
- W645171471 type Work @default.
- W645171471 sameAs 645171471 @default.
- W645171471 citedByCount "3" @default.
- W645171471 countsByYear W6451714712012 @default.
- W645171471 crossrefType "journal-article" @default.
- W645171471 hasAuthorship W645171471A5018004018 @default.
- W645171471 hasAuthorship W645171471A5024099273 @default.
- W645171471 hasAuthorship W645171471A5055851463 @default.
- W645171471 hasConcept C104317684 @default.
- W645171471 hasConcept C105580179 @default.
- W645171471 hasConcept C140704245 @default.
- W645171471 hasConcept C149364088 @default.
- W645171471 hasConcept C159047783 @default.
- W645171471 hasConcept C2522874641 @default.
- W645171471 hasConcept C3675279 @default.
- W645171471 hasConcept C54355233 @default.
- W645171471 hasConcept C86803240 @default.
- W645171471 hasConcept C95444343 @default.
- W645171471 hasConceptScore W645171471C104317684 @default.
- W645171471 hasConceptScore W645171471C105580179 @default.
- W645171471 hasConceptScore W645171471C140704245 @default.
- W645171471 hasConceptScore W645171471C149364088 @default.
- W645171471 hasConceptScore W645171471C159047783 @default.
- W645171471 hasConceptScore W645171471C2522874641 @default.
- W645171471 hasConceptScore W645171471C3675279 @default.
- W645171471 hasConceptScore W645171471C54355233 @default.
- W645171471 hasConceptScore W645171471C86803240 @default.
- W645171471 hasConceptScore W645171471C95444343 @default.
- W645171471 hasLocation W6451714711 @default.
- W645171471 hasOpenAccess W645171471 @default.
- W645171471 hasPrimaryLocation W6451714711 @default.
- W645171471 hasRelatedWork W1994769674 @default.
- W645171471 hasRelatedWork W2038904951 @default.
- W645171471 hasRelatedWork W2046328332 @default.
- W645171471 hasRelatedWork W2049636398 @default.
- W645171471 hasRelatedWork W2060261905 @default.
- W645171471 hasRelatedWork W2082627738 @default.
- W645171471 hasRelatedWork W2097192208 @default.
- W645171471 hasRelatedWork W2101026659 @default.
- W645171471 hasRelatedWork W2102032614 @default.
- W645171471 hasRelatedWork W2107777605 @default.
- W645171471 hasRelatedWork W2108822954 @default.
- W645171471 hasRelatedWork W2113363982 @default.
- W645171471 hasRelatedWork W2252205516 @default.
- W645171471 hasRelatedWork W2411153978 @default.
- W645171471 hasRelatedWork W2588030737 @default.
- W645171471 hasRelatedWork W2901354538 @default.
- W645171471 hasRelatedWork W2947671543 @default.
- W645171471 hasRelatedWork W327211136 @default.
- W645171471 hasRelatedWork W584816468 @default.
- W645171471 hasRelatedWork W646980015 @default.
- W645171471 hasVolume "48" @default.
- W645171471 isParatext "false" @default.
- W645171471 isRetracted "false" @default.
- W645171471 magId "645171471" @default.
- W645171471 workType "article" @default.