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- W64561952 abstract "Asthma and other allergic diseases have become increasingly common in the latter part of the 20th century. Allergic reactions in the airways are triggered by immunoglobulin E (IgE) sensitized mast cells and T-helper 2 (Th2) CD4+ T-cells, whose activation leads to the infiltration of other inflammatory cells, which contribute to tissue damage. One-third of all circulating T-cells are CD8+/CD4−. These cells are found at all immune sites and are particularly prominent in mucosal tissues, where they provide a first line of defense fulfilling an immunological gatekeeper function (1,2). CD8+ T-cells recognize intracellular antigens presented via major histocompatibility complex (MHC) class I and are more cytolytic than CD4+ T-cells, producing perforin and degradative enzymes such as granzyme B. CD8+ T-cells can kill MHC class-I peptide-bearing target cells via the Fas-dependent “kiss-of-death” pathway. In this chapter we will review the role of CD8+ T-cells in IgE regulation." @default.
- W64561952 created "2016-06-24" @default.
- W64561952 creator A5011069259 @default.
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- W64561952 date "1998-01-01" @default.
- W64561952 modified "2023-09-26" @default.
- W64561952 title "Role of CD8+ T-Cells in the Regulation of Immunoglobulin E" @default.
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- W64561952 doi "https://doi.org/10.1007/978-1-4757-2776-0_13" @default.
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