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- W64565315 abstract "ATP-sensitive K+ channels (KAgp channels) were first described in cardiac myocytes (1) and were subsequently found in many other tissues including pancreatic 13-cells (25), skeletal muscle (6), smooth muscle (7), brain (8), pituitary (9), and kidney (10) and in mitochondria (11). KA,p channels were originally characterized by inhibition when the ATP concentration at the cytoplasmic surface was increased (12). It is now known that regulation of KATP channel activity is complex, involving factors including nucleotide diphosphates such as ADP, Mgt*, and phosphatidylinositol bisphosphate (13-18). KATP channels play important roles in endocrine cells, muscles, and neurones, by coupling metabolic state to membrane potential (12,19,20). In pancreatic 13 cells, KATP channels regulate glucose-induced insulin secretion. Inhibition of the KATP channels by glucose depolarizes the 13-cell membrane, leading to opening of the voltage-dependent calcium channels (VDCCs), and allowing calcium influx. The rise in intracellular calcium concentration ([Ca21) in the 13-cell triggers exocytosis of the insulin granules. While the K+ channel opener diazoxide inhibits insulin secretion by activating the KATP channels, sulfonylureas such as glibenclamide, which is widely used in the treatment of type 2 diabetes mellitus, stimulate insulin release by inhibiting the KATP channels (21,22) Fig1 The cloning of members of the inwardly rectifying K+ channel subfamily Kir6.0 and the sulfonylurea receptors has clarified the structure of KA,p channels and revealed a new paradigm of channel/receptor assembly." @default.
- W64565315 created "2016-06-24" @default.
- W64565315 creator A5028420497 @default.
- W64565315 creator A5046353080 @default.
- W64565315 creator A5091860088 @default.
- W64565315 date "2001-01-01" @default.
- W64565315 modified "2023-09-27" @default.
- W64565315 title "The KATP Channel and the Sulfonylurea Receptor" @default.
- W64565315 cites W124504601 @default.
- W64565315 cites W1753089048 @default.
- W64565315 cites W1958062876 @default.
- W64565315 cites W1965209959 @default.
- W64565315 cites W1967307504 @default.
- W64565315 cites W1968008917 @default.
- W64565315 cites W1980007713 @default.
- W64565315 cites W1980347800 @default.
- W64565315 cites W1983011541 @default.
- W64565315 cites W1985770721 @default.
- W64565315 cites W1986381180 @default.
- W64565315 cites W1986804446 @default.
- W64565315 cites W1989576630 @default.
- W64565315 cites W1990845205 @default.
- W64565315 cites W1993854078 @default.
- W64565315 cites W1993911643 @default.
- W64565315 cites W1994924615 @default.
- W64565315 cites W1995589371 @default.
- W64565315 cites W1996162664 @default.
- W64565315 cites W1997849672 @default.
- W64565315 cites W2003847682 @default.
- W64565315 cites W2005150634 @default.
- W64565315 cites W2010666880 @default.
- W64565315 cites W2010710963 @default.
- W64565315 cites W2012164977 @default.
- W64565315 cites W2012181178 @default.
- W64565315 cites W2015251758 @default.
- W64565315 cites W2017903601 @default.
- W64565315 cites W2018570817 @default.
- W64565315 cites W2019024229 @default.
- W64565315 cites W2019710821 @default.
- W64565315 cites W2021925516 @default.
- W64565315 cites W2022092956 @default.
- W64565315 cites W2022446120 @default.
- W64565315 cites W2025901527 @default.
- W64565315 cites W2029414905 @default.
- W64565315 cites W2030223575 @default.
- W64565315 cites W2032485738 @default.
- W64565315 cites W2032897738 @default.
- W64565315 cites W2033478528 @default.
- W64565315 cites W2034158559 @default.
- W64565315 cites W2042432366 @default.
- W64565315 cites W2042683979 @default.
- W64565315 cites W2044165578 @default.
- W64565315 cites W2046377775 @default.
- W64565315 cites W2047169350 @default.
- W64565315 cites W2051677297 @default.
- W64565315 cites W2056283223 @default.
- W64565315 cites W2059328843 @default.
- W64565315 cites W2061158658 @default.
- W64565315 cites W2061787346 @default.
- W64565315 cites W2061988480 @default.
- W64565315 cites W2063574029 @default.
- W64565315 cites W2064953660 @default.
- W64565315 cites W2066650398 @default.
- W64565315 cites W2068118359 @default.
- W64565315 cites W2070184989 @default.
- W64565315 cites W2070276658 @default.
- W64565315 cites W2071786252 @default.
- W64565315 cites W2074306054 @default.
- W64565315 cites W2077873945 @default.
- W64565315 cites W2082648108 @default.
- W64565315 cites W2083584165 @default.
- W64565315 cites W2086345475 @default.
- W64565315 cites W2086491850 @default.
- W64565315 cites W2087893458 @default.
- W64565315 cites W2091668532 @default.
- W64565315 cites W2095512900 @default.
- W64565315 cites W2097248117 @default.
- W64565315 cites W2103806994 @default.
- W64565315 cites W2110696115 @default.
- W64565315 cites W2115936507 @default.
- W64565315 cites W2129668416 @default.
- W64565315 cites W2134133830 @default.
- W64565315 cites W2147762436 @default.
- W64565315 cites W2148255642 @default.
- W64565315 cites W2148959338 @default.
- W64565315 cites W2152682266 @default.
- W64565315 cites W2162088190 @default.
- W64565315 cites W2162097287 @default.
- W64565315 cites W2172211138 @default.
- W64565315 cites W2250052379 @default.
- W64565315 cites W2322041353 @default.
- W64565315 cites W2330339020 @default.
- W64565315 cites W4229630474 @default.
- W64565315 cites W4232141068 @default.
- W64565315 cites W4232990065 @default.
- W64565315 cites W4240259609 @default.
- W64565315 cites W4241768020 @default.
- W64565315 cites W4243454973 @default.