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- W645745332 abstract "Recently, high levels of serum lipoprotein (a) (Lp (a)) have been reported in connection with coronary atherosclerosis. However, little is known about the relationship of Lp (a) levels to the severity of coronary atherosclerosis.We measured Lp (a) levels in 98 patients undergoing diagnostic coronary angiography (CAG group) and in 18 healthy subjects (control). The CAG group was divided into four subgroups by the number of the three involved major coronary vessels possessing more than 75% stenosis (0, 1, 2, 3 VD), and the quantitative coronary lesion score (CS) of each CAG group patient was estimated by Gensini's method.Lp (a) was measured by the single radial immunodiffusion method, while cholesterol (TC) and triglyceride (TG) were measured by the enzymatic method, HDL-cholesterol (HDL) by the precipitation method, apolipoprotein A1 and B (apo A1, apo B) by the turbidometric immunoassay method, and LCAT by Akanuma's method. The LDL-cholesterol (LDL) was calculated by Friedewald's formula.The mean value of the Lp (a) levels was 22.1mg/dl, and the median was 19.4mg/dl. The mean Lp (a) level was 8.9mg/dl in the controls, 8.7mg/dl in 0 VD, 22.6mg/dl in 1 VD, 25.8mg/dl in 2 VD, 36.4mg/dl in 3 VD. The Lp (a) level was significantly associated with the number of vessels involved by the non-parametric statistical method. CS was significantly correlated with Lp (a), TC, LDL and apo A1 levels or LDL/HDL, LDL/TC, and the apo B/A1 ratios by univariate analysis. However, the level of serum Lp (a) was not correlated with other lipids, lipoproteins, apolipoproteins, age, or the body mass index. The frequency of a high Lp (a) level over 20mg/dl was not associated with diabetes, hypertension, smoking, gender, or old age (over 50 years old).Thus, serum Lp (a) levels appear to be a risk factor in initiating and enhancing coronary atherosclerosis." @default.
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- W645745332 date "1991-01-01" @default.
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- W645745332 title "Effects of the Serum Lipoprotein (a) Level on the Severity of Coronary Atherosclerosis" @default.
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- W645745332 doi "https://doi.org/10.5551/jat1973.19.9-10_823" @default.
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