Matches in SemOpenAlex for { <https://semopenalex.org/work/W64588397> ?p ?o ?g. }
- W64588397 endingPage "202" @default.
- W64588397 startingPage "194" @default.
- W64588397 abstract "In a search for a mechanism to explain the impaired growth of progenitor cells in patients with myelodysplastic syndromes (MDS), marrow CD34+ cells were purified up to 94.9% +/- 4.2% for normal individuals and 88.1% +/- 17.6% for MDS patients, using monoclonal antibodies and immunomagnetic microspheres (MDS CD34+ cells). Phenotypic subpopulations of these CD34+ cells were analyzed for CD38, HLA-DR, CD33, CD13, CD14, CD41 and CD3 plus CD19, in association with proliferative and differentiative capacities. The 15 studies performed included 12 MDS patients. Coexpression rate of CD13 significantly increased in the MDS CD34+ cell population with a value of 91.4% +/- 11.6% and ranging from 60.3% to 100%, and exceeded 99% in four studies, whereas that of normal CD34+ cells was 49.9% +/- 15.8%, ranging from 28.2% to 70.1% (P < .001). Coexpression rate of CD38, HLA-DR, CD33, CD14, and CD3 plus CD19 in MDS CD34+ cells did not significantly differ from that of normal CD34+ cells. The total number of colonies and clusters grown from 100 normal marrow CD34+ cells was 40.4 +/- 8.6, the range being from 27.2 to 50.3; this varied in MDS marrow CD34+ cells with a value of 34.0 +/- 28.7, the range being 0 to 95.9. The lineage of colonies and clusters promoted by MDS marrow CD34+ cells was predominantly committed to nonerythroid with impaired differentiation in 13 of 15 studies (87%). CD13 is first expressed during hematopoiesis by colony-forming unit granulocyte-macrophage and is absent in erythroid progenitors. Therefore, this study provides direct evidence for the lineage commitment of MDS CD34+ cells to nonerythroid with impaired differentiation and explains the mechanism of nil or low colony expression of MDS progenitor cells to erythroid lineage." @default.
- W64588397 created "2016-06-24" @default.
- W64588397 creator A5013672387 @default.
- W64588397 creator A5019829851 @default.
- W64588397 creator A5039214377 @default.
- W64588397 creator A5047200285 @default.
- W64588397 creator A5053803963 @default.
- W64588397 creator A5072369550 @default.
- W64588397 creator A5073548226 @default.
- W64588397 creator A5073878198 @default.
- W64588397 creator A5078000437 @default.
- W64588397 creator A5091623593 @default.
- W64588397 date "1995-01-01" @default.
- W64588397 modified "2023-10-16" @default.
- W64588397 title "Proliferation and differentiation of myelodysplastic CD34+ cells: phenotypic subpopulations of marrow CD34+ cells" @default.
- W64588397 cites W113943006 @default.
- W64588397 cites W1480768564 @default.
- W64588397 cites W1493755175 @default.
- W64588397 cites W1504611261 @default.
- W64588397 cites W1590042948 @default.
- W64588397 cites W1789486470 @default.
- W64588397 cites W1880227053 @default.
- W64588397 cites W1972394840 @default.
- W64588397 cites W1973348421 @default.
- W64588397 cites W1987683022 @default.
- W64588397 cites W1991116274 @default.
- W64588397 cites W1991206650 @default.
- W64588397 cites W1995440539 @default.
- W64588397 cites W2010267536 @default.
- W64588397 cites W2011548691 @default.
- W64588397 cites W2018821773 @default.
- W64588397 cites W2028924492 @default.
- W64588397 cites W2032502279 @default.
- W64588397 cites W2045911327 @default.
- W64588397 cites W2046517797 @default.
- W64588397 cites W2051139434 @default.
- W64588397 cites W2051444689 @default.
- W64588397 cites W2051769615 @default.
- W64588397 cites W2068926092 @default.
- W64588397 cites W2076493808 @default.
- W64588397 cites W2087934471 @default.
- W64588397 cites W2094552370 @default.
- W64588397 cites W2106045733 @default.
- W64588397 cites W217622729 @default.
- W64588397 cites W2410364212 @default.
- W64588397 cites W2411074463 @default.
- W64588397 cites W2411687618 @default.
- W64588397 cites W2417474187 @default.
- W64588397 cites W2419384495 @default.
- W64588397 cites W2474698873 @default.
- W64588397 cites W2475224020 @default.
- W64588397 cites W30255411 @default.
- W64588397 cites W3115630352 @default.
- W64588397 cites W339316500 @default.
- W64588397 cites W6285716 @default.
- W64588397 cites W64700562 @default.
- W64588397 cites W74017565 @default.
- W64588397 cites W86828079 @default.
- W64588397 cites W1983392832 @default.
- W64588397 cites W2415453968 @default.
- W64588397 doi "https://doi.org/10.1182/blood.v85.1.194.bloodjournal851194" @default.
- W64588397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7528567" @default.
- W64588397 hasPublicationYear "1995" @default.
- W64588397 type Work @default.
- W64588397 sameAs 64588397 @default.
- W64588397 citedByCount "53" @default.
- W64588397 countsByYear W645883972013 @default.
- W64588397 countsByYear W645883972014 @default.
- W64588397 countsByYear W645883972018 @default.
- W64588397 countsByYear W645883972022 @default.
- W64588397 countsByYear W645883972023 @default.
- W64588397 crossrefType "journal-article" @default.
- W64588397 hasAuthorship W64588397A5013672387 @default.
- W64588397 hasAuthorship W64588397A5019829851 @default.
- W64588397 hasAuthorship W64588397A5039214377 @default.
- W64588397 hasAuthorship W64588397A5047200285 @default.
- W64588397 hasAuthorship W64588397A5053803963 @default.
- W64588397 hasAuthorship W64588397A5072369550 @default.
- W64588397 hasAuthorship W64588397A5073548226 @default.
- W64588397 hasAuthorship W64588397A5073878198 @default.
- W64588397 hasAuthorship W64588397A5078000437 @default.
- W64588397 hasAuthorship W64588397A5091623593 @default.
- W64588397 hasBestOaLocation W645883971 @default.
- W64588397 hasConcept C10205521 @default.
- W64588397 hasConcept C109159458 @default.
- W64588397 hasConcept C147483822 @default.
- W64588397 hasConcept C153911025 @default.
- W64588397 hasConcept C159912055 @default.
- W64588397 hasConcept C176290653 @default.
- W64588397 hasConcept C196166836 @default.
- W64588397 hasConcept C201750760 @default.
- W64588397 hasConcept C203014093 @default.
- W64588397 hasConcept C2778957590 @default.
- W64588397 hasConcept C2779282312 @default.
- W64588397 hasConcept C2780007613 @default.
- W64588397 hasConcept C28328180 @default.
- W64588397 hasConcept C2908647359 @default.
- W64588397 hasConcept C502942594 @default.