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- W646061013 abstract "Natural killer cells (NK) belong to a heterogenous group of cells primarily thought to function against tumors. However, additional studies have indicated a broader role for these cells in immune regulation, including the regulation of B cells. Peripherial blood lymphocytes from rheumatoid arthritis (RA) patients and normal individuals were purified into three groups: T, B, and NK cells. Purity of these populations was assessed by Facs analysis (94%, 90% and 86% respectively.) These cells were used in a proliferative assay to determine the affects of NK cells on polyclonal proliferation of B cells. The normal and rheumatoid arthritis patients were previously assessed in terms of a proliferative response to recall antigen and designated as either anergic (non-responsive) or non-anergic (responsive). Inhibition of B cell proliferative response was seen in the normal (-35% ± 4.5) and non-anergic subgroup (-25.6 ± 3.8), but not in the anergic subgroup (+11.2 ±7.8). While removal of the CD57+ NK cells did not reverse the inhibition seen in the normal or non-anergic individuals, elimination of the CD16+ cells did (-1 ± 0.816 and 6.4 ± 6.5 respectively), with no significant effect on the anergic subpopulation. To investigate the dependence of this NK regulation on T cells, CD8+ T cells were removed. While there was no significant difference seen in the inhibition levels in the normal and non-anergic groups, inhibition in the anergic population Significantly increased. This work suggests that NK cells are involved in limiting the proliferative response of activated B cells and this is dependent on the" @default.
- W646061013 created "2016-06-24" @default.
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- W646061013 date "1990-01-01" @default.
- W646061013 modified "2023-09-23" @default.
- W646061013 title "The effects of NK cells on the proliferation of B cells in individuals with rheumatoid arthritis." @default.
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