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- W64608895 abstract "Bacterial artificial chromosomes (BACs) are large genomic clones that are stably maintained in Escherichia coli . Because they are frequently large enough to contain an entire gene and its associated regulatory elements, BACs can serve as a source of gene-specific promoter sequences. The large size of BACs has necessitated the development of recombination-based methods to modify these DNAs. Transgenic mice containing BACs engineered to express reporter genes have been shown to mark discrete populations of cells. Therefore, BACs serve as a tool that should greatly facilitate our ability to manipulate gene expression in specific cell types in the nervous system." @default.
- W64608895 created "2016-06-24" @default.
- W64608895 creator A5091077014 @default.
- W64608895 date "2009-01-01" @default.
- W64608895 modified "2023-09-24" @default.
- W64608895 title "BAC Transgenesis: Cell-Type Specific Expression in the Nervous System" @default.
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- W64608895 doi "https://doi.org/10.1016/b978-008045046-9.00869-x" @default.
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