FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W64634433> ?p ?o ?g. }

• W64634433 endingPage "506" @default.
• W64634433 startingPage "473" @default.
• W64634433 abstract "It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin secretion is the essential element in the progression of patients from a state of impaired glucose tolerance to frank type 2 diabetes (Del Prato, 2003, Del Prato and Tiengo, 2001). Although extensive studies have examined the molecular, cellular and physiologic mechanisms of insulin granule biogenesis, sorting, and exocytosis the precise mechanisms controlling these processes and their dysregulation in the developed of diabetes remains an area of important investigation. We now know that insulin biogenesis initiates with the synthesis of preproinsulin in rough endoplastic reticulum and conversion of preproinsulin to proinsulin. Proinsulin begins to be packaged in the Trans‐Golgi Network and is sorting into immature secretory granules. These immature granules become acidic via ATP‐dependent proton pump and proinsulin undergoes proteolytic cleavage resulting the formation of insulin and C‐peptide. During the granule maturation process, insulin is crystallized with zinc and calcium in the form of dense‐core granules and unwanted cargo and membrane proteins undergo selective retrograde trafficking to either the constitutive trafficking pathway for secretion or to degradative pathways. The newly formed mature dense‐core insulin granules populate two different intracellular pools, the readily releasable pools (RRP) and the reserved pool. These two distinct populations are thought to be responsible for the biphasic nature of insulin release in which the RRP granules are associated with the plasma membrane and undergo an acute calcium‐dependent release accounting for first phase insulin secretion. In contrast, second phase insulin secretion requires the trafficking of the reserved granule pool to the plasma membrane. The initial trigger for insulin granule fusion with the plasma membrane is a rise in intracellular calcium and in the case of glucose stimulation results from increased production of ATP, closure of the ATP‐sensitive potassium channel and cellular depolarization. In turn, this opens voltage‐dependent calcium channels allowing increased influx of extracellular calcium. Calcium is thought to bind to members of the fusion regulatory proteins synaptogamin that functionally repressors the fusion inhibitory protein complexin. Both complexin and synaptogamin interact as well as several other regulatory proteins interact with the core fusion machinery composed of the Q‐ or t‐SNARE proteins syntaxin 1 and SNAP25 in the plasma membrane that assembles with the R‐ or v‐SNARE protein VAMP2 in insulin granules. In this chapter we will review the current progress of insulin granule biogenesis, sorting, trafficking, exocytosis and signaling pathways that comprise the molecular basis of glucose‐dependent insulin secretion." @default.
• W64634433 created "2016-06-24" @default.
• W64634433 creator A5019410316 @default.
• W64634433 creator A5077728712 @default.
• W64634433 creator A5086369520 @default.
• W64634433 date "2009-01-01" @default.
• W64634433 modified "2023-09-29" @default.
• W64634433 title "Chapter 16 Insulin Granule Biogenesis, Trafficking and Exocytosis" @default.
• W64634433 cites W1012070930 @default.
• W64634433 cites W135689210 @default.
• W64634433 cites W1507712770 @default.
• W64634433 cites W1549549099 @default.
• W64634433 cites W1552892404 @default.
• W64634433 cites W1562863707 @default.
• W64634433 cites W1567005075 @default.
• W64634433 cites W1590230114 @default.
• W64634433 cites W1612279088 @default.
• W64634433 cites W1737157464 @default.
• W64634433 cites W1788294099 @default.
• W64634433 cites W1793850395 @default.
• W64634433 cites W181267088 @default.
• W64634433 cites W1866455211 @default.
• W64634433 cites W1881432776 @default.
• W64634433 cites W1962657470 @default.
• W64634433 cites W1964123359 @default.
• W64634433 cites W1964597228 @default.
• W64634433 cites W1965316807 @default.
• W64634433 cites W1965893090 @default.
• W64634433 cites W1967434228 @default.
• W64634433 cites W1967965496 @default.
• W64634433 cites W1968021596 @default.
• W64634433 cites W1968720990 @default.
• W64634433 cites W1970249565 @default.
• W64634433 cites W1975250137 @default.
• W64634433 cites W1976953486 @default.
• W64634433 cites W1977685486 @default.
• W64634433 cites W1978800429 @default.
• W64634433 cites W1978982233 @default.
• W64634433 cites W1980405692 @default.
• W64634433 cites W1980815431 @default.
• W64634433 cites W1981344194 @default.
• W64634433 cites W1981363187 @default.
• W64634433 cites W1981697489 @default.
• W64634433 cites W1983009379 @default.
• W64634433 cites W1983127906 @default.
• W64634433 cites W1983737411 @default.
• W64634433 cites W1984975071 @default.
• W64634433 cites W1985829064 @default.
• W64634433 cites W1987736310 @default.
• W64634433 cites W1988196562 @default.
• W64634433 cites W1988532766 @default.
• W64634433 cites W1988850305 @default.
• W64634433 cites W1989688231 @default.
• W64634433 cites W1990482183 @default.
• W64634433 cites W1991824197 @default.
• W64634433 cites W1992163176 @default.
• W64634433 cites W1994026558 @default.
• W64634433 cites W1994284052 @default.
• W64634433 cites W1996598000 @default.
• W64634433 cites W1997124286 @default.
• W64634433 cites W1998012015 @default.
• W64634433 cites W1998130425 @default.
• W64634433 cites W1999103393 @default.
• W64634433 cites W1999565511 @default.
• W64634433 cites W2003045046 @default.
• W64634433 cites W2004564781 @default.
• W64634433 cites W2004797151 @default.
• W64634433 cites W2006943139 @default.
• W64634433 cites W2008411184 @default.
• W64634433 cites W2008657624 @default.
• W64634433 cites W2010986301 @default.
• W64634433 cites W2011132236 @default.
• W64634433 cites W2011571924 @default.
• W64634433 cites W2012623603 @default.
• W64634433 cites W2013617213 @default.
• W64634433 cites W2013832366 @default.
• W64634433 cites W2013985904 @default.
• W64634433 cites W2014732107 @default.
• W64634433 cites W2014784442 @default.
• W64634433 cites W2014894301 @default.
• W64634433 cites W2015001567 @default.
• W64634433 cites W2015974998 @default.
• W64634433 cites W2016417523 @default.
• W64634433 cites W2016516993 @default.
• W64634433 cites W2017427555 @default.
• W64634433 cites W2017509811 @default.
• W64634433 cites W2017902030 @default.
• W64634433 cites W2019253192 @default.
• W64634433 cites W2020821717 @default.
• W64634433 cites W2021465933 @default.
• W64634433 cites W2022101780 @default.
• W64634433 cites W2027536811 @default.
• W64634433 cites W2030630673 @default.
• W64634433 cites W2031212561 @default.
• W64634433 cites W2032763961 @default.
• W64634433 cites W2033797809 @default.
• W64634433 cites W2035214813 @default.
• W64634433 cites W2035537554 @default.

• next