FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W646567365> ?p ?o ?g. }

• W646567365 endingPage "1238" @default.
• W646567365 startingPage "1183" @default.
• W646567365 abstract "Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are associated with a mortality rate of 15 to 60%. The first report of S. aureus resistant to penicillin occurred in 1942. A series of glycopeptides was prepared at Shionogi and displayed good in vitro anti-MRSA activity, with MICs ranging from 0.20 to 6.25 µg/ml. Daptomycin possesses an unusual amino acid, kynurenine. Modifications of this amino acid were attempted on the ketone and anilino groups. These modifications highlighted the importance of this amino acid for antibacterial activity. One of the most effective antibacterial strategies is to disrupt the integrity of bacterial cell wall formation. Peptidoglycan includes four steps in which amino acid residues are ligated to uridine-diphospho-N-acetylmuramic acid (UDP-MurNac). Benzylidene rhodamine is an inhibitor of MurC and is active against MRSA (MICs, 31 µM). A series of derivatives was synthesized, with the aim of improving logP and water solubility, as well as protein binding. Molecular iron is an essential factor for bacterial growth, iron being used during respiration, DNA replication, and other biological processes. One of the targets of a research was to improve water solubility, to obtain in vivo activity against MRSA, and to obtain both anti-MRSA activity and activity against gram-negative bacteria, including Pseudomonas aeruginosa. Deformylase is an essential bacterial metallo-enzyme responsible for the removal of the N-terminal formyl group from methionine following protein synthesis. Methionine aminopeptidases play a pivotal role in protein biosynthesis." @default.
• W646567365 created "2016-06-24" @default.
• W646567365 creator A5059999356 @default.
• W646567365 date "2014-04-30" @default.
• W646567365 modified "2023-09-25" @default.
• W646567365 title "Agents against Methicillin-Resistant Staphylococcus aureus" @default.
• W646567365 cites W1861947080 @default.
• W646567365 cites W1893457360 @default.
• W646567365 cites W1966193550 @default.
• W646567365 cites W1967121489 @default.
• W646567365 cites W1967189967 @default.
• W646567365 cites W1969290393 @default.
• W646567365 cites W1969855620 @default.
• W646567365 cites W1971806815 @default.
• W646567365 cites W1972349129 @default.
• W646567365 cites W1973321602 @default.
• W646567365 cites W1973611487 @default.
• W646567365 cites W1975273750 @default.
• W646567365 cites W1978000002 @default.
• W646567365 cites W1978328486 @default.
• W646567365 cites W1980208466 @default.
• W646567365 cites W1982898709 @default.
• W646567365 cites W1985250360 @default.
• W646567365 cites W1985315189 @default.
• W646567365 cites W1985508970 @default.
• W646567365 cites W1987123834 @default.
• W646567365 cites W1989526018 @default.
• W646567365 cites W1990816255 @default.
• W646567365 cites W1991757465 @default.
• W646567365 cites W1995173701 @default.
• W646567365 cites W1997320387 @default.
• W646567365 cites W1998050289 @default.
• W646567365 cites W1999617256 @default.
• W646567365 cites W2000715286 @default.
• W646567365 cites W2001355968 @default.
• W646567365 cites W2003108643 @default.
• W646567365 cites W2003279445 @default.
• W646567365 cites W2003379019 @default.
• W646567365 cites W2003571575 @default.
• W646567365 cites W2005180659 @default.
• W646567365 cites W2010235673 @default.
• W646567365 cites W2010746820 @default.
• W646567365 cites W2011682491 @default.
• W646567365 cites W2014223232 @default.
• W646567365 cites W2015465189 @default.
• W646567365 cites W2015821358 @default.
• W646567365 cites W2015853029 @default.
• W646567365 cites W2016401457 @default.
• W646567365 cites W2017204498 @default.
• W646567365 cites W2022766724 @default.
• W646567365 cites W2030894388 @default.
• W646567365 cites W2034846673 @default.
• W646567365 cites W2035939070 @default.
• W646567365 cites W2036391575 @default.
• W646567365 cites W2036819571 @default.
• W646567365 cites W2037976634 @default.
• W646567365 cites W2039424050 @default.
• W646567365 cites W2040270061 @default.
• W646567365 cites W2043082319 @default.
• W646567365 cites W2045499035 @default.
• W646567365 cites W2045988032 @default.
• W646567365 cites W2049465402 @default.
• W646567365 cites W2051932642 @default.
• W646567365 cites W2053887084 @default.
• W646567365 cites W2057233489 @default.
• W646567365 cites W2058714090 @default.
• W646567365 cites W2060405277 @default.
• W646567365 cites W2060539863 @default.
• W646567365 cites W2061128386 @default.
• W646567365 cites W2063534911 @default.
• W646567365 cites W2063563175 @default.
• W646567365 cites W2064052293 @default.
• W646567365 cites W2065700218 @default.
• W646567365 cites W2067064359 @default.
• W646567365 cites W2069262414 @default.
• W646567365 cites W2069996627 @default.
• W646567365 cites W2070114047 @default.
• W646567365 cites W2072524630 @default.
• W646567365 cites W2073633384 @default.
• W646567365 cites W2075110964 @default.
• W646567365 cites W2075248402 @default.
• W646567365 cites W2075554206 @default.
• W646567365 cites W2078389099 @default.
• W646567365 cites W2078777478 @default.
• W646567365 cites W2079406318 @default.
• W646567365 cites W2079590397 @default.
• W646567365 cites W2081058839 @default.
• W646567365 cites W2082892394 @default.
• W646567365 cites W2082893974 @default.
• W646567365 cites W2085812687 @default.
• W646567365 cites W2086407199 @default.
• W646567365 cites W2087485426 @default.
• W646567365 cites W2088632301 @default.
• W646567365 cites W2090969764 @default.
• W646567365 cites W2091981254 @default.
• W646567365 cites W2092489849 @default.
• W646567365 cites W2093212356 @default.
• W646567365 cites W2093481189 @default.

• next