Matches in SemOpenAlex for { <https://semopenalex.org/work/W64679923> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W64679923 endingPage "47.13" @default.
- W64679923 startingPage "47.13" @default.
- W64679923 abstract "Abstract Peripheral T cells undergo apoptosis induced by repeated TCR stimulation, known as activation-induced cell death (ACID), which plays an important role in T-cell tolerance. AICD in CD4 T helper (Th) cells including Th1 and Th2 effectors has been extensively studied. Recently, IL-17-producing CD4+ T cells (Th17 cells) have been identified as a unique Th subset, but the susceptibility and underneath molecular mechanism of AICD in Th17 effectors have not been defined. In this study, we found that Th17 cells were significantly less susceptible to AICD upon TCR restimulation compared to Th1 cells. The resistance was confirmed on pure Th17 cells by gating on CD4+RFP+ cells that were polarized from CD4 naïve T cells from il17f/rfp knock-in mice. Furthermore, the resistance of Th17 cells to AICD was also observed when Th17 cells were co-cultured in vitro or co-injected in vivo with Th1 cells. To explore the molecular mechanism, we found that Th17 cells were defective in FasL expression and in caspase activation, but highly expressed anti-apoptotic protein c-FLIP. After knocking down c-FLIP with its specific siRNA, Th17 cells re-expressed FasL and underwent rapid apoptosis upon TCR restimulation. In conclusion, Th17 cells are resistant to AICD likely because the high level of c-FLIP prevents Fas-mediated apoptosis. The resistance of Th17 cells to AICD reveals additional mechanism to explain the high pathogenicity of Th17 cells in autoimmune diseases, and may also provide a rationale to generate tumor-specific Th17 cells for adoptive cell immunotherapy." @default.
- W64679923 created "2016-06-24" @default.
- W64679923 creator A5059611399 @default.
- W64679923 creator A5060783496 @default.
- W64679923 creator A5062170722 @default.
- W64679923 creator A5064062544 @default.
- W64679923 creator A5069553630 @default.
- W64679923 creator A5077157954 @default.
- W64679923 date "2009-04-01" @default.
- W64679923 modified "2023-09-23" @default.
- W64679923 title "Resistance of Th17 cells to Activation-Induced Cell Death (47.13)" @default.
- W64679923 doi "https://doi.org/10.4049/jimmunol.182.supp.47.13" @default.
- W64679923 hasPublicationYear "2009" @default.
- W64679923 type Work @default.
- W64679923 sameAs 64679923 @default.
- W64679923 citedByCount "0" @default.
- W64679923 crossrefType "journal-article" @default.
- W64679923 hasAuthorship W64679923A5059611399 @default.
- W64679923 hasAuthorship W64679923A5060783496 @default.
- W64679923 hasAuthorship W64679923A5062170722 @default.
- W64679923 hasAuthorship W64679923A5064062544 @default.
- W64679923 hasAuthorship W64679923A5069553630 @default.
- W64679923 hasAuthorship W64679923A5077157954 @default.
- W64679923 hasConcept C153911025 @default.
- W64679923 hasConcept C185592680 @default.
- W64679923 hasConcept C190283241 @default.
- W64679923 hasConcept C19317047 @default.
- W64679923 hasConcept C203014093 @default.
- W64679923 hasConcept C2776090121 @default.
- W64679923 hasConcept C31573885 @default.
- W64679923 hasConcept C55493867 @default.
- W64679923 hasConcept C86803240 @default.
- W64679923 hasConcept C8891405 @default.
- W64679923 hasConcept C95444343 @default.
- W64679923 hasConceptScore W64679923C153911025 @default.
- W64679923 hasConceptScore W64679923C185592680 @default.
- W64679923 hasConceptScore W64679923C190283241 @default.
- W64679923 hasConceptScore W64679923C19317047 @default.
- W64679923 hasConceptScore W64679923C203014093 @default.
- W64679923 hasConceptScore W64679923C2776090121 @default.
- W64679923 hasConceptScore W64679923C31573885 @default.
- W64679923 hasConceptScore W64679923C55493867 @default.
- W64679923 hasConceptScore W64679923C86803240 @default.
- W64679923 hasConceptScore W64679923C8891405 @default.
- W64679923 hasConceptScore W64679923C95444343 @default.
- W64679923 hasIssue "1_Supplement" @default.
- W64679923 hasLocation W646799231 @default.
- W64679923 hasOpenAccess W64679923 @default.
- W64679923 hasPrimaryLocation W646799231 @default.
- W64679923 hasRelatedWork W138661586 @default.
- W64679923 hasRelatedWork W1987695408 @default.
- W64679923 hasRelatedWork W2067043854 @default.
- W64679923 hasRelatedWork W2069667446 @default.
- W64679923 hasRelatedWork W2355246966 @default.
- W64679923 hasRelatedWork W2747317233 @default.
- W64679923 hasRelatedWork W2931523797 @default.
- W64679923 hasRelatedWork W2991146262 @default.
- W64679923 hasRelatedWork W4306155276 @default.
- W64679923 hasRelatedWork W4377862087 @default.
- W64679923 hasVolume "182" @default.
- W64679923 isParatext "false" @default.
- W64679923 isRetracted "false" @default.
- W64679923 magId "64679923" @default.
- W64679923 workType "article" @default.