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- W64692922 abstract "Aim. To compare information value of antihypertensive effect equability parameters for two drug formulations of nifedipine: long-acting one (nifedipine-XL) and short-acting one (nifedipine-sa). Material and methods. 147 patients with arterial hypertension (age 53,8±12,5 years) were included into multicenter, cross over design study. Duration of wash-out period was 2 weeks; duration of each treatment course 4 weeks; interval between courses 1 week. The following doses of drugs were used: nifedipine-XL 30-60 mg once daily, nifedipine-sa 10-20 mg three times a day. Daily blood pressure monitoring (DBPM -Schiller BR-102) was made initially, at the end of each treatment course and at the end of interval between courses. To assess the equability of drug antihypertensive effect smoothness index (SI) and coefficient trough effect/peak effect were used (COTP). Information value of these indexes (treatment vs. initial) was assessed by the logical regress analysis. Results. Nifedipine-XL and nifedipine-sa had significant antihypertensive effect according to DBPM data and clinical measurements. Equability of both drugs was similar. χ2 Wald range was 14,7-18,7 (p" @default.
- W64692922 created "2016-06-24" @default.
- W64692922 creator A5023983739 @default.
- W64692922 creator A5030187797 @default.
- W64692922 creator A5053743441 @default.
- W64692922 date "2005-01-01" @default.
- W64692922 modified "2023-09-23" @default.
- W64692922 title "Оценка равномерности антигипертензивного эффекта двух лекарственных форм нифедипина с помощью суточного мониторирования артериального давления" @default.
- W64692922 hasPublicationYear "2005" @default.
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