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• W64694851 abstract "ABCG2 is known to efflux folates and dihydrotestosterone, both of which are important for prostate tumor growth. Recently the Q141K variant of ABCG2, which decreases the function of ABCG2, was found to have an impact on survival time in prostate cancer (PCa) patients. In addition, ABCG2 may be involved in cellular resistance to docetaxel, a chemotherapeutic used to treat late-stage PCa. Because ABCG2 function appears to be correlated with survival times and may transport molecules important in prostate growth and cancer treatment, it is crucial to understand its expression, function, and regulation in PCa. An observed CpG island in the ABCG2 promoter indicates the potential for regulation by DNA methylation. Accordingly, transcription of ABCG2 was increased after treatment with a DNA methyltransferase inhibitor. Furthermore, PCa cell lines grown in a folate deficient environment increased the expression of ABCG2, which was due to hypomethylation of the ABCG2 promoter. Patients with recurrent PCa carrying the Q141K variant of ABCG2 had a significantly shorter time to PSA recurrence post-prostatectomy than patients carrying the wild-type allele. Transport studies showed that the Q141K variant expressing HEK293 cells retained more folic acid than their wild-type counterparts, and surprisingly, patients carrying the Q141K variant had decreased systemic folate levels. Furthermore, while it was known that docetaxel-treated PCa patients carrying the Q141K variant have a longer survival time, we found this is likely because ABCG2 plays a role in docetaxel efflux. PCa cell lines were highly resistant to forced expression of exogenous ABCG2. This was due in part to induced expression of two miRNAs known to repress ABCG2 in other cancer cell lines. In conclusion, the Q141K variant appears to play opposing roles in prostate cancer. By decreasing folate efflux, intracellular folate levels and cell proliferation increase, but docetaxel treatment can increase tumor-cell drug sensitivity, which increases patient survival time. Our enhanced understanding of the varied docetaxel response among patients as well as evidence that ABCG2 is an as of yet unforeseen, major player in regulation of systemic folate levels may have implications in determining a personalized treatment plan for a cancer patient based on their ABCG2 genotype." @default.
• W64694851 created "2016-06-24" @default.
• W64694851 creator A5038522695 @default.
• W64694851 date "2013-12-17" @default.
• W64694851 modified "2023-09-27" @default.
• W64694851 title "Regulation, Function, and Clinical Relevance of ABCG2 in Prostate Cancer" @default.
• W64694851 cites W1481699366 @default.
• W64694851 cites W1787401899 @default.
• W64694851 cites W1874417368 @default.
• W64694851 cites W1910056530 @default.
• W64694851 cites W1931116526 @default.
• W64694851 cites W1963895296 @default.
• W64694851 cites W1964705588 @default.
• W64694851 cites W1965256036 @default.
• W64694851 cites W1968129452 @default.
• W64694851 cites W1968145453 @default.
• W64694851 cites W1968428572 @default.
• W64694851 cites W1971053454 @default.
• W64694851 cites W1975018672 @default.
• W64694851 cites W1977668920 @default.
• W64694851 cites W1978211686 @default.
• W64694851 cites W1983876627 @default.
• W64694851 cites W1985051375 @default.
• W64694851 cites W1985582440 @default.
• W64694851 cites W1988172699 @default.
• W64694851 cites W1989061195 @default.
• W64694851 cites W1993373855 @default.
• W64694851 cites W1995975317 @default.
• W64694851 cites W1996189033 @default.
• W64694851 cites W1996443605 @default.
• W64694851 cites W1997069890 @default.
• W64694851 cites W1997167043 @default.
• W64694851 cites W1998291676 @default.
• W64694851 cites W1999004536 @default.
• W64694851 cites W2002795755 @default.
• W64694851 cites W2002864331 @default.
• W64694851 cites W2006998846 @default.
• W64694851 cites W2007602523 @default.
• W64694851 cites W2009035156 @default.
• W64694851 cites W2013064901 @default.
• W64694851 cites W2013932133 @default.
• W64694851 cites W2014426079 @default.
• W64694851 cites W2017190497 @default.
• W64694851 cites W2017927877 @default.
• W64694851 cites W2019562735 @default.
• W64694851 cites W2020933463 @default.
• W64694851 cites W2021428758 @default.
• W64694851 cites W2026449959 @default.
• W64694851 cites W2028533496 @default.
• W64694851 cites W2029851742 @default.
• W64694851 cites W2033020367 @default.
• W64694851 cites W2034426081 @default.
• W64694851 cites W2036459315 @default.
• W64694851 cites W2037995961 @default.
• W64694851 cites W2043747831 @default.
• W64694851 cites W2044444556 @default.
• W64694851 cites W2046792018 @default.
• W64694851 cites W2047705797 @default.
• W64694851 cites W2048558726 @default.
• W64694851 cites W2048729835 @default.
• W64694851 cites W2049772927 @default.
• W64694851 cites W2051086992 @default.
• W64694851 cites W2051167270 @default.
• W64694851 cites W2051216049 @default.
• W64694851 cites W2051687016 @default.
• W64694851 cites W2051835394 @default.
• W64694851 cites W2052209393 @default.
• W64694851 cites W2058763609 @default.
• W64694851 cites W2059149893 @default.
• W64694851 cites W2061773900 @default.
• W64694851 cites W2068586232 @default.
• W64694851 cites W2068875547 @default.
• W64694851 cites W2070691527 @default.
• W64694851 cites W2074887652 @default.
• W64694851 cites W2075293629 @default.
• W64694851 cites W2076174476 @default.
• W64694851 cites W2077197798 @default.
• W64694851 cites W2077673548 @default.
• W64694851 cites W2078330324 @default.
• W64694851 cites W2079016515 @default.
• W64694851 cites W2082843436 @default.
• W64694851 cites W2085979770 @default.
• W64694851 cites W2090705949 @default.
• W64694851 cites W2090915667 @default.
• W64694851 cites W2093011419 @default.
• W64694851 cites W2098560357 @default.
• W64694851 cites W2100260797 @default.
• W64694851 cites W2103082218 @default.
• W64694851 cites W2103879666 @default.
• W64694851 cites W2104283475 @default.
• W64694851 cites W2104409728 @default.
• W64694851 cites W2104711019 @default.
• W64694851 cites W2106382671 @default.
• W64694851 cites W2106795666 @default.
• W64694851 cites W2108349673 @default.
• W64694851 cites W2109279065 @default.
• W64694851 cites W2113665122 @default.
• W64694851 cites W2117150909 @default.
• W64694851 cites W2117612044 @default.
• W64694851 cites W2119283265 @default.

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