Matches in SemOpenAlex for { <https://semopenalex.org/work/W646955071> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W646955071 abstract "The actin driven motility of eukaryotic cells has been one of the most rapidly developing research areas in biology over the last decades. Polymerization and depolymerization of filaments is the driving force behind the crawling motion of individual cells. There is a large variety of proteins known or suspected to be involved in this polymerization machinery. The question arises which of them are essential for the ability of a cell to move directionally. Many studies have been conducted on cells which are already in motion or at least polarized with established lamellipods, and several mechanisms have been shown to be essential for sustaining the large movement velocities observed in vivo. The question we addressed here is what minimal requirements have to be met by a non polarized resting cell to react to an external stimulus in a prescribed direction. For that purpose, we develop a minimal model for actin turnover, examine its steady states, and try to figure out which types of perturbations are most appropriate to turn the cytoskeleton into a polarized state which may be viewed as the beginning of directed motion. We analyze a one dimensional model for a resting cell describing the actin network therein. For the time being we restrict ourselves to describing the dynamics of barbed ends accumulating near the cell membrane. Pushing the membrane forward and establishing a lamellipod would be the next step in the initiation of movement and shall be investigated in future. In our simulations we found that very few mechanisms are sufficient to create a significant modification of the cytoskeleton. Moreover we see a striking effect of the diffusion coefficient for the actin monomers on the strength of this modification." @default.
- W646955071 created "2016-06-24" @default.
- W646955071 creator A5017365819 @default.
- W646955071 creator A5033830372 @default.
- W646955071 creator A5062121632 @default.
- W646955071 date "2006-09-15" @default.
- W646955071 modified "2023-09-27" @default.
- W646955071 title "Actin Dynamics and Cell Motility: Minimal Models for the Initiation of Cell Movement" @default.
- W646955071 cites W1983645902 @default.
- W646955071 cites W2012915205 @default.
- W646955071 cites W2017471444 @default.
- W646955071 cites W2038940222 @default.
- W646955071 cites W2047668778 @default.
- W646955071 cites W2057472297 @default.
- W646955071 cites W2058096164 @default.
- W646955071 cites W2060614996 @default.
- W646955071 cites W2074008387 @default.
- W646955071 cites W2103247257 @default.
- W646955071 cites W2126496496 @default.
- W646955071 cites W2130851152 @default.
- W646955071 cites W2166927847 @default.
- W646955071 cites W2396211831 @default.
- W646955071 cites W591909594 @default.
- W646955071 hasPublicationYear "2006" @default.
- W646955071 type Work @default.
- W646955071 sameAs 646955071 @default.
- W646955071 citedByCount "0" @default.
- W646955071 crossrefType "journal-article" @default.
- W646955071 hasAuthorship W646955071A5017365819 @default.
- W646955071 hasAuthorship W646955071A5033830372 @default.
- W646955071 hasAuthorship W646955071A5062121632 @default.
- W646955071 hasConcept C121332964 @default.
- W646955071 hasConcept C12554922 @default.
- W646955071 hasConcept C125705527 @default.
- W646955071 hasConcept C142669718 @default.
- W646955071 hasConcept C145912823 @default.
- W646955071 hasConcept C1491633281 @default.
- W646955071 hasConcept C15744967 @default.
- W646955071 hasConcept C160408235 @default.
- W646955071 hasConcept C169760540 @default.
- W646955071 hasConcept C185592680 @default.
- W646955071 hasConcept C24890656 @default.
- W646955071 hasConcept C2779918689 @default.
- W646955071 hasConcept C542102704 @default.
- W646955071 hasConcept C54355233 @default.
- W646955071 hasConcept C58207958 @default.
- W646955071 hasConcept C86803240 @default.
- W646955071 hasConcept C95444343 @default.
- W646955071 hasConceptScore W646955071C121332964 @default.
- W646955071 hasConceptScore W646955071C12554922 @default.
- W646955071 hasConceptScore W646955071C125705527 @default.
- W646955071 hasConceptScore W646955071C142669718 @default.
- W646955071 hasConceptScore W646955071C145912823 @default.
- W646955071 hasConceptScore W646955071C1491633281 @default.
- W646955071 hasConceptScore W646955071C15744967 @default.
- W646955071 hasConceptScore W646955071C160408235 @default.
- W646955071 hasConceptScore W646955071C169760540 @default.
- W646955071 hasConceptScore W646955071C185592680 @default.
- W646955071 hasConceptScore W646955071C24890656 @default.
- W646955071 hasConceptScore W646955071C2779918689 @default.
- W646955071 hasConceptScore W646955071C542102704 @default.
- W646955071 hasConceptScore W646955071C54355233 @default.
- W646955071 hasConceptScore W646955071C58207958 @default.
- W646955071 hasConceptScore W646955071C86803240 @default.
- W646955071 hasConceptScore W646955071C95444343 @default.
- W646955071 hasLocation W6469550711 @default.
- W646955071 hasOpenAccess W646955071 @default.
- W646955071 hasPrimaryLocation W6469550711 @default.
- W646955071 hasRelatedWork W1011279037 @default.
- W646955071 hasRelatedWork W1985764672 @default.
- W646955071 hasRelatedWork W2007250557 @default.
- W646955071 hasRelatedWork W2007847670 @default.
- W646955071 hasRelatedWork W2037363728 @default.
- W646955071 hasRelatedWork W2046754542 @default.
- W646955071 hasRelatedWork W2056000602 @default.
- W646955071 hasRelatedWork W2060066670 @default.
- W646955071 hasRelatedWork W2087857172 @default.
- W646955071 hasRelatedWork W2336241371 @default.
- W646955071 hasRelatedWork W2394816543 @default.
- W646955071 hasRelatedWork W2582174445 @default.
- W646955071 hasRelatedWork W2584884893 @default.
- W646955071 hasRelatedWork W2897606034 @default.
- W646955071 hasRelatedWork W2899339800 @default.
- W646955071 hasRelatedWork W2946839756 @default.
- W646955071 hasRelatedWork W2948446146 @default.
- W646955071 hasRelatedWork W2953896150 @default.
- W646955071 hasRelatedWork W3159352358 @default.
- W646955071 hasRelatedWork W2738019143 @default.
- W646955071 isParatext "false" @default.
- W646955071 isRetracted "false" @default.
- W646955071 magId "646955071" @default.
- W646955071 workType "article" @default.