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- W64696869 abstract "More than two-thirds of all known G-protein coupled receptors are known to modulate the function of adenylate cyclase resulting in altered levels of cAMP. In turn, cAMP fluctuations transform agonist binding events into physiological changes in cell behavior. The advent of nonradioactive, homogeneous methods of measuring intracellular cAMP has enabled the rapid growth of drug discovery and research applications for these GPCR targets. In this chapter, we describe a nonradioactive, chemiluminescent cAMP detection method using enzyme fragment complementation technology to detect a wide range of GPCR modulators which is also suitable for high-throughput screening." @default.
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- W64696869 date "2012-01-01" @default.
- W64696869 modified "2023-09-26" @default.
- W64696869 title "Characterization of G-Protein Coupled Receptor Modulators Using Homogeneous cAMP Assays" @default.
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- W64696869 doi "https://doi.org/10.1007/978-1-61779-909-9_8" @default.
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