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• W64697629 abstract "The involvement of the phospholipase C (PLC) pathway in the non-genomic regulation of duodenal cell Ca2+ concentration by 17β-oestradiol was investigated. The PLC inhibitors neomycin (0.5 mM) and U-73122 (2 µM) suppressed the stimulatory effect of 0.1 nM 17β-oestradiol on the 45Ca2+ influx into enterocytes isolated from rat duodenum. The hormone (1 pM to 10 nM) increased the formation of 1,2-diacylglycerol in a biphasic pattern, characterized by an early peak at 45 s (+82%) and a later peak at 5 min (+46%). Both PLC inhibitors suppressed the first peak but were unable to block the 17β-oestradiol effect at 5 min. 17β-Oestradiol also increased the generation of inositol 1,4,5-trisphosphate within 15 s, with maximal stimulation at 30 s. 17β-Oestradiol induced a rapid (30 s) and sustained (up to 5 min) increase in the intracellular Ca2+ concentration ([Ca2+]i) of fura 2-loaded enterocytes. The fast rise in [Ca2+]i was specific because other sex steroid hormones were without effect and could be blocked to a great extent by U-73122 (by 86% at 1 min). The effects of 17β-oestradiol on enterocyte [Ca2+]i were decreased significantly (by 75%) in a Ca2+-free extracellular medium but a pronounced increase in [Ca2+]i was obtained after readmission of Ca2+ to the medium. The latter change was suppressed by 10 µM La3+, whereas nitrendipine (1 µM) and verapamil (10 µM) separately were without effect. The permeability of the 17β-oestradiol-induced Ca2+ influx pathway to Mn2+ was increased 2.8-fold by treatment with oestrogen. These results suggest the operation of a PLC-dependent store-operated Ca2+ channel mechanism in 17β-oestradiol regulation of enterocyte extracellular Ca2+ influx." @default.
• W64697629 created "2016-06-24" @default.
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• W64697629 date "1999-03-25" @default.
• W64697629 modified "2023-09-27" @default.
• W64697629 title "17β-Oestradiol increases intracellular Ca2+ concentration in rat enterocytes" @default.
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• W64697629 doi "https://doi.org/10.1042/bj3390071" @default.
• W64697629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220129" @default.
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