FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W647269780> ?p ?o ?g. }

• W647269780 endingPage "124" @default.
• W647269780 startingPage "115" @default.
• W647269780 abstract "Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients. This study develops a bubble carrier system by loading diethylene triamine pentaacetic acid (DTPA) dianhydride, a foaming agent (sodium bicarbonate; SBC), a surfactant (sodium dodecyl sulfate; SDS), and a protein drug (insulin) in an enteric-coated gelatin capsule. Following oral administration to diabetic rats, the intestinal fluid that has passed through the gelatin capsule saturates the mixture; concomitantly, DTPA dianhydride produces an acidic environment, while SBC decomposes to form CO2 bubbles at acidic pH. The gas bubbles grow among the surfactant molecules (SDS) owing to the expansion of the generated CO2. The walls of the CO2 bubbles consist of a self-assembled film of water that is in nanoscale and may serve as a colloidal carrier to transport insulin and DTPA. The grown gas bubbles continue to expand until they bump into the wall and burst, releasing their transported insulin, DTPA, and SDS into the mucosal layer. The released DTPA and SDS function as protease inhibitors to protect the insulin molecules as well as absorption enhancers to augment their epithelial permeability and eventual absorption into systemic circulation, exerting their hypoglycemic effects." @default.
• W647269780 created "2016-06-24" @default.
• W647269780 creator A5005351122 @default.
• W647269780 creator A5008387139 @default.
• W647269780 creator A5026217046 @default.
• W647269780 creator A5031673772 @default.
• W647269780 creator A5031779031 @default.
• W647269780 creator A5038953479 @default.
• W647269780 creator A5049002632 @default.
• W647269780 creator A5058832480 @default.
• W647269780 creator A5063689491 @default.
• W647269780 date "2015-09-01" @default.
• W647269780 modified "2023-10-16" @default.
• W647269780 title "Self-assembling bubble carriers for oral protein delivery" @default.
• W647269780 cites W1549826455 @default.
• W647269780 cites W1592968628 @default.
• W647269780 cites W1969875587 @default.
• W647269780 cites W1970039861 @default.
• W647269780 cites W1975983454 @default.
• W647269780 cites W1985015502 @default.
• W647269780 cites W1991061036 @default.
• W647269780 cites W1991603251 @default.
• W647269780 cites W1999663860 @default.
• W647269780 cites W2006036698 @default.
• W647269780 cites W2006373622 @default.
• W647269780 cites W2014307717 @default.
• W647269780 cites W2028309493 @default.
• W647269780 cites W2029006305 @default.
• W647269780 cites W2033400171 @default.
• W647269780 cites W2041016731 @default.
• W647269780 cites W2060253137 @default.
• W647269780 cites W2061121954 @default.
• W647269780 cites W2061733847 @default.
• W647269780 cites W2069235788 @default.
• W647269780 cites W2087421919 @default.
• W647269780 cites W2089407496 @default.
• W647269780 cites W2101161388 @default.
• W647269780 cites W2108719148 @default.
• W647269780 cites W2126462892 @default.
• W647269780 cites W2147519497 @default.
• W647269780 cites W2148700019 @default.
• W647269780 cites W2151279676 @default.
• W647269780 cites W2320482766 @default.
• W647269780 cites W4362217335 @default.
• W647269780 doi "https://doi.org/10.1016/j.biomaterials.2015.06.035" @default.
• W647269780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26132436" @default.
• W647269780 hasPublicationYear "2015" @default.
• W647269780 type Work @default.
• W647269780 sameAs 647269780 @default.
• W647269780 citedByCount "25" @default.
• W647269780 countsByYear W6472697802016 @default.
• W647269780 countsByYear W6472697802017 @default.
• W647269780 countsByYear W6472697802018 @default.
• W647269780 countsByYear W6472697802019 @default.
• W647269780 countsByYear W6472697802020 @default.
• W647269780 countsByYear W6472697802021 @default.
• W647269780 countsByYear W6472697802022 @default.
• W647269780 crossrefType "journal-article" @default.
• W647269780 hasAuthorship W647269780A5005351122 @default.
• W647269780 hasAuthorship W647269780A5008387139 @default.
• W647269780 hasAuthorship W647269780A5026217046 @default.
• W647269780 hasAuthorship W647269780A5031673772 @default.
• W647269780 hasAuthorship W647269780A5031779031 @default.
• W647269780 hasAuthorship W647269780A5038953479 @default.
• W647269780 hasAuthorship W647269780A5049002632 @default.
• W647269780 hasAuthorship W647269780A5058832480 @default.
• W647269780 hasAuthorship W647269780A5063689491 @default.
• W647269780 hasConcept C125287762 @default.
• W647269780 hasConcept C127413603 @default.
• W647269780 hasConcept C134018914 @default.
• W647269780 hasConcept C157915830 @default.
• W647269780 hasConcept C159985019 @default.
• W647269780 hasConcept C173608175 @default.
• W647269780 hasConcept C178790620 @default.
• W647269780 hasConcept C185592680 @default.
• W647269780 hasConcept C191897082 @default.
• W647269780 hasConcept C192562407 @default.
• W647269780 hasConcept C2778778583 @default.
• W647269780 hasConcept C2778823387 @default.
• W647269780 hasConcept C2778913249 @default.
• W647269780 hasConcept C2779306644 @default.
• W647269780 hasConcept C41008148 @default.
• W647269780 hasConcept C42360764 @default.
• W647269780 hasConcept C43617362 @default.
• W647269780 hasConcept C537181965 @default.
• W647269780 hasConcept C55493867 @default.
• W647269780 hasConcept C58226133 @default.
• W647269780 hasConcept C59789625 @default.
• W647269780 hasConcept C59822182 @default.
• W647269780 hasConcept C71924100 @default.
• W647269780 hasConcept C76155785 @default.
• W647269780 hasConcept C84403425 @default.
• W647269780 hasConcept C86803240 @default.
• W647269780 hasConceptScore W647269780C125287762 @default.
• W647269780 hasConceptScore W647269780C127413603 @default.
• W647269780 hasConceptScore W647269780C134018914 @default.
• W647269780 hasConceptScore W647269780C157915830 @default.
• W647269780 hasConceptScore W647269780C159985019 @default.

• next