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- W647455654 abstract "Cyclodextrins are cyclic (α-1,4)-linked oligosaccharides of α-D-glucopyranose derived from starch. They differ from one another by the number of glucopyranose units in the structure. Cyclodextrins can be classified in two groups: natural and modified. The most common natural cyclodextrins are α-cyclodextrin, β–cyclodextrin andι γ-cyclodextrin which consist of six, seven and eight glucopyranose units respectively. Also, modified cyclodextrins offer significant advantages in comparison with natural cyclodextrins.The cyclodextrin structure provides a molecule shaped like a segment of a hollow cone with an exterior hydrophilic surface and interior hydrophobic cavity. The hydrophilic surface generates good water solubility for the cyclodextrin and the hydrophobic cavity provides a favorable environment in which the entire or part of the drug molecule is fitted. Cyclodextrins can interact with appropriately sized molecules to result in the formation of inclusion compounds. Inclusion complex formation between cyclodextrins and drugs often modifies the physical and chemical properties of the guest molecules.Cyclodextrin complexation has been successfully used to improve solubility, dissolution rate, chemical stability and bioavailability of sparingly soluble or insoluble drugs. Also, cyclodextrins can be used to reduce or eliminate unpleasant smell or tastes of drugs, prevent drug-drug or drug-additive interactions and reduce or prevent drug side effects.Itraconazole is an orally broad-spectrum triazole antifungal agent, which is practically insoluble in water at physiological conditions and more soluble only in extremely acidic media, leading to poor oral biovailability. ITZ is a very poorly water soluble, weak base. The aqueous solubility is estimated at ~ 1ng/ml at neutral pH and ~ 4μg/ml at pH = 1. [2] The chemical structure of ITZ is shown in Figure 1. The cyclodextrins tested in this work were : Hydroxypropyl-β-Cyclodextrin (HP-β-CD), Methyl-β-Cyclodextrin (Me-β-CD), Hydroxyethyl-β-Cyclodextrin (He-β-CD) and Hydroxypropyl-γ-Cyclodextrin (HP-γ-CD).The aims of this work are: to evaluate the influence of above cyclodextrins on the solubility of ITZ at acified aqueous solutions to characterize the solid complexes formed between cyclodextrins and ITZ prepared by different techniques." @default.
- W647455654 created "2016-06-24" @default.
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- W647455654 date "2007-07-23" @default.
- W647455654 modified "2023-09-27" @default.
- W647455654 title "Μελέτη της επίδρασης των κυκλοδεξτρινών στη διαλυτότητα της ιτρακοναζόλης" @default.
- W647455654 hasPublicationYear "2007" @default.
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