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- W647510522 abstract "Receptor/ligand interactions that dominate the control of natural killer (NK) cell activity likely differ in detail among vertebrate species as the result of natural selection. We are interested in innate immune responses in the avian species that serve as alternate hosts for pathogens causing human disease. We would like to link the challenge of pathogens to the genetics of NK cell activity. We are applying a largely unbiased high throughput proteomic approach to identify components of the surface of chicken NK cells. Our goal is to develop methods for preparing membrane fractions in abundance so that rare proteins, e.g. NK cell receptors, can be detected by mass spectrometry. We are comparing different fractionation methods for the capacity to provide membrane proteins from embryonic spleen cells that exhibit natural cytotoxic activity. We found it necessary to enhance the yield of membrane proteins since simpler methods are inadequate. We are now comparing methods incorporating fractionation by relative hydrophobicity and by shotgun glycopeptides capture. NK cell surface proteins identified by molecular biology serve as controls in evaluating purification. Supported in part by NSF MCB-0524167" @default.
- W647510522 created "2016-06-24" @default.
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- W647510522 date "2008-03-01" @default.
- W647510522 modified "2023-09-24" @default.
- W647510522 title "Proteomic Approaches to Defining Avian Natural Killer Cell Surface Proteins" @default.
- W647510522 doi "https://doi.org/10.1096/fasebj.22.1_supplement.620.3" @default.
- W647510522 hasPublicationYear "2008" @default.
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