Matches in SemOpenAlex for { <https://semopenalex.org/work/W647532454> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W647532454 abstract "Neurointensive care (NIC) has gained terrain in the treatment of patients with various acute cerebral conditions. It is based on the concept that an unfavorable clinical outcome, to a certain extent, results from all secondary ischemic insults sustained by the brain during the acute phase of the disease. This thesis covers a clinical longitudinal study of the consequences of the introduction of NIC for overall management and outcome of 873 patients with aneurysmal subarachnoid hemorrhage (SAH) over a 12-year period, and neurochemical phenomena monitored by intracerebral microdialysis (MD) in a subgroup of patients with serious SAH.Progressive awareness of the emergency nature of the disease with faster referral, increasing patient age and severity of neurological condition emerged with time. Management was characterized by a more aggressive approach with greater use of computerized tomography, angiography, artificial ventilation, ventriculostomy, pharmacological and surgical treatment in a NIC unit. The most striking results were a gradual reduction in mortality rate and improved clinical outcome, particularly in patients with Hunt and Hess Grades I to II SAH, and in those with intraventricular hemorrhage. The frequency of talk and die patients (conscious on admission who eventually died) also decreased dramatically. A pattern of focal ischemic perturbation with zero levels of glucose, increased lactate/pyruvate (L/P) ratios and glutamate concentrations was identified. Furthermore a presumably global cerebral hypermetabolism strongly associated with a good outcome was found. The detection of this favorable prognostic metabolic pattern may become a new important indication for MD in NIC. Different neurochemical profiles in neurologically similar patients may result from early events after the SAH. Therefore further implementation of ultra-early resuscitative measures and treatment may enhance the brain's capacity to react and cope with the extreme metabolic demands elicited by the SAH and thus promote neurological restoration." @default.
- W647532454 created "2016-06-24" @default.
- W647532454 creator A5001082210 @default.
- W647532454 date "1999-11-01" @default.
- W647532454 modified "2023-09-27" @default.
- W647532454 title "Neurointensive Care of Subarachnoid Hemorrhage: Clinical and Neurochemical Aspects" @default.
- W647532454 hasPublicationYear "1999" @default.
- W647532454 type Work @default.
- W647532454 sameAs 647532454 @default.
- W647532454 citedByCount "0" @default.
- W647532454 crossrefType "book" @default.
- W647532454 hasAuthorship W647532454A5001082210 @default.
- W647532454 hasConcept C126322002 @default.
- W647532454 hasConcept C165455791 @default.
- W647532454 hasConcept C25876315 @default.
- W647532454 hasConcept C2777736543 @default.
- W647532454 hasConcept C2778376644 @default.
- W647532454 hasConcept C2779234561 @default.
- W647532454 hasConcept C2779252433 @default.
- W647532454 hasConcept C42219234 @default.
- W647532454 hasConcept C54355233 @default.
- W647532454 hasConcept C71924100 @default.
- W647532454 hasConcept C86803240 @default.
- W647532454 hasConceptScore W647532454C126322002 @default.
- W647532454 hasConceptScore W647532454C165455791 @default.
- W647532454 hasConceptScore W647532454C25876315 @default.
- W647532454 hasConceptScore W647532454C2777736543 @default.
- W647532454 hasConceptScore W647532454C2778376644 @default.
- W647532454 hasConceptScore W647532454C2779234561 @default.
- W647532454 hasConceptScore W647532454C2779252433 @default.
- W647532454 hasConceptScore W647532454C42219234 @default.
- W647532454 hasConceptScore W647532454C54355233 @default.
- W647532454 hasConceptScore W647532454C71924100 @default.
- W647532454 hasConceptScore W647532454C86803240 @default.
- W647532454 hasLocation W6475324541 @default.
- W647532454 hasOpenAccess W647532454 @default.
- W647532454 hasPrimaryLocation W6475324541 @default.
- W647532454 hasRelatedWork W1044854056 @default.
- W647532454 hasRelatedWork W1598681777 @default.
- W647532454 hasRelatedWork W1964023476 @default.
- W647532454 hasRelatedWork W1997581621 @default.
- W647532454 hasRelatedWork W1998048316 @default.
- W647532454 hasRelatedWork W2006959081 @default.
- W647532454 hasRelatedWork W2038324191 @default.
- W647532454 hasRelatedWork W2038693068 @default.
- W647532454 hasRelatedWork W2051368211 @default.
- W647532454 hasRelatedWork W2052223963 @default.
- W647532454 hasRelatedWork W2085268501 @default.
- W647532454 hasRelatedWork W2155300399 @default.
- W647532454 hasRelatedWork W2187038820 @default.
- W647532454 hasRelatedWork W2196064099 @default.
- W647532454 hasRelatedWork W2416718119 @default.
- W647532454 hasRelatedWork W2592318780 @default.
- W647532454 hasRelatedWork W2793517483 @default.
- W647532454 hasRelatedWork W2896692831 @default.
- W647532454 hasRelatedWork W3110796222 @default.
- W647532454 hasRelatedWork W54291257 @default.
- W647532454 isParatext "false" @default.
- W647532454 isRetracted "false" @default.
- W647532454 magId "647532454" @default.
- W647532454 workType "book" @default.