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- W647675672 abstract "The paper describes a skin morphological examination using an immunohistochemical study (Ki-67, cytokeratin (CK) 5/6, and CK LMW) in a dead 4-month-old girl with congenital ichthyosis (Harlequin ichthyosis (HI)). There is impaired proliferative activity, abnormalities in epidermal differentiation with abnormal CK LMW synthesis, and those in the differentiation of the skin appendages. There are also pronounced sclerotic changes with a predominance of reticulin fibers, derma, and its vessels. The patient with HI and trichoepithelioma is noted to have the similar immunohistochemical phenotype of hair bulbs.Приведено морфологическое исследование кожи с использованием иммуногистохимического исследования (Ki-67, СK 5/6, СK LMW) у умершей четырехмесячной девочки с врожденным ихтиозом (ихтиоз Арлекино). Выявлены нарушения пролиферативной активности, дифференцировки эпидермиса с аномальным синтезом СK LMW, а также дифференцировки придатков кожи. Обнаружены выраженные склеротические изменения с преобладанием ретикулиновых волокон, дермы и ее сосудов. Отмечен сходный иммуногистохимический фенотип волосяных луковиц и трихоэпителиомы." @default.
- W647675672 created "2016-06-24" @default.
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- W647675672 date "2015-01-01" @default.
- W647675672 modified "2023-09-27" @default.
- W647675672 title "Skin morphology in congenital ichthyosis (Arlequin fetus)" @default.
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- W647675672 doi "https://doi.org/10.17116/patol201577239-42" @default.
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