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- W64788498 abstract "Homocystinuria was firstly described in 1962 en children with learning difficulties, and in 1969 McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in children with elevated plasma homocysteine concentrations and homocystinuria. Homocysteine, a sulfur amino acid, is an intermediate metabolite of methionine, and in the both cases mentioned, on the basis of these finding biochemical, they proposed that elevated plasma homocysteine (hyperhomocysteinemia) can cause neural injury and atherosclerotic vascular disease. Hyperhomocysteinemia is now well established as an independent risk factor for atherosclerotic vascular disease. Mild hyperhomocysteinemia is quite prevalent in the general population. It can be caused by genetic defects in the enzymes involved in homocysteine metabolism or nutritional deficiencies in vitamin cofactors, certain medications, high methionie intake or renal disease. The homocysteine concentration can be lowered with folate, and itis so vitamin supplementation has thus been proposed in individuals with hyperhomocysteinemia in order to reduce their cardiovascular disease risk. In this article, we review the biology, pathobiology and bioclinic of the metabolism of homocysteine." @default.
- W64788498 created "2016-06-24" @default.
- W64788498 creator A5027720893 @default.
- W64788498 date "2010-01-01" @default.
- W64788498 modified "2023-09-27" @default.
- W64788498 title "BIOLOG˝A, PATOBIOLOG˝A Y BIOCL˝NICA DE LA HOMOCISTE˝NA EN LA ESPECIE HUMANA" @default.
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